DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-PheRS and FDXACB1

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_612387.1	Gene:	FDXACB1 / 91893	HGNCID:	25110	Length:	624	Species:	Homo sapiens

Alignment Length:	225	Identity:	42/225 - (18%)
Similarity:	76/225 - (33%)	Gaps:	59/225 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 LLQETTTKSFVLARGPEFATTLTKLETDLTVEMLANGLWDQLKFKAYNFD-------ALGAPPTR 220
            ||.:|..:|             :||.:.:...:.:||....::.|.:||.       .:|:..|.
Human   422 LLTQTLPES-------------SKLSSLVKFVLQSNGKDYMIRVKTHNFSPDCTEDLIIGSVITS 473

  Fly   221 GHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSF---WNFDALYQPQQHPARDAHDTFFVNHPA 282
            .    ...:..:...:|:.|....:....:..|.:   |.||..:.....|.:        ..|.
Human   474 A----TSVIHKDQCFVFVSMNLDLLAMLVWCISDWRMLWTFDNRFLKNFVPGK--------IEPF 526

  Fly   283 KSHK-FPQDYLERVKKVHSVGGYGSKGYGYDWKLE-------EAQKNLLR-------THTTAVSA 332
            |||. :|..|      ||.|..:..:..|:| :||       .:|..::.       .|......
Human   527 KSHSLYPPCY------VHDVSFWIDQKKGFD-ELEFHTVARAVSQDTIISIQFLSRFQHPKTQQV 584

  Fly   333 RMLYKLANQ--EGGFKAAKYFSIDKVFRNE 360
            .:.|:|..|  :......:..|:...||.|
Human   585 SLCYRLTYQTCDKALTQQQVASMQSQFRKE 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	42/225 (19%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	29/157 (18%)
FDXACB1	NP_612387.1	DUF2431	7..176	CDD:287341
FDXACB1	NP_612387.1	FDX-ACB	530..624	CDD:214893	18/92 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810