Protein Alignment alpha-PheRS and FRS2

DIOPT Version :10

• Sequence 1: NP_572448.1
• Gene: alpha-PheRS / 31740
• FlyBaseID: FBgn0030007
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_116631.1
• Gene: FRS2 / 850522
• SGDID: S000001872
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 500
• Identity: 249/500 - (49%)
• Similarity: 324/500 - (64%)
• Gaps: 23/500 - (4%)

  Fly    13 LETTDKADTLD-----LAALFAEDHQKIVGSLKSIQAHG--ELVTAETVTHKSLGLTDEGRAVVE 70
            ||...|.|.||     ||.......|.::.:|.|::||.  |....:|||:   .||.||..::.
Yeast     6 LEILKKLDELDEIKSTLATFPQHGSQDVLSALNSLKAHNKLEFSKVDTVTY---DLTKEGAQILN 67

  Fly    71 NGSHEALVYDLVPPEGIAQA--ALMAAGGANAKVGFSKAMSHGWILVDKS----VTPPLVRRKVD 129
            .||:|..:..|:...|..|.  .:...|....|||.::|..:|||..:.|    ::..|....::
Yeast    68 EGSYEIKLVKLIQELGQLQIKDVMSKLGPQVGKVGQARAFKNGWIAKNASNELELSAKLQNTDLN 132

  Fly   130 TITDVVRNQLQQVALGKG-DQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTV 193
            .:||..::.|.|:..... |.:.||.:.|.|||||:.:.....|.:.:||||:|.|||||||||.
Yeast   133 ELTDETQSILAQIKNNSHLDSIDAKILNDLKKRKLIAQGKITDFNVTKGPEFSTDLTKLETDLTS 197

  Fly   194 EMLANGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNF 258
            :|::...:..||||.|||::.|...:.|.||||.|||.||||||..|||:|||:|.|||:.||||
Yeast   198 DMVSTNAYKDLKFKPYNFNSQGVQISSGALHPLNKVREEFRQIFFSMGFTEMPSNQYVETGFWNF 262

  Fly   259 DALYQPQQHPARDAHDTFFVNHPAKSHKFPQD--YLERVKKVHSVGGYGSKGYGYDWKLEEAQKN 321
            ||||.||||||||..|||::..|..: ..|.|  |::.:|.||..|.:||.||.|:||.||.||.
Yeast   263 DALYVPQQHPARDLQDTFYIKDPLTA-DLPDDKTYMDNIKAVHEQGRFGSIGYRYNWKPEECQKL 326

  Fly   322 LLRTHTTAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGD 386
            :||||:||:|||||:.||...   |..:.||||:|||||.:||||||||||||||:||..:||||
Yeast   327 VLRTHSTAISARMLHDLAKDP---KPTRLFSIDRVFRNEAVDATHLAEFHQVEGVLADYNITLGD 388

  Fly   387 LIGTLYEFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPEN 451
            ||..:.|||.::|:|.|.|||.||||||||||||.:|.||.||:|:||||:||||||..||||::
Yeast   389 LIKFMEEFFERMGVTGLRFKPTYNPYTEPSMEIFSWHEGLQKWVEIGNSGMFRPEMLESMGLPKD 453

  Fly   452 VNVIAWGLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            :.|:.|||||||||||||.:.|||:|:|.||.|..:|..|..|||
Yeast   454 LRVLGWGLSLERPTMIKYKVQNIRELLGHKVSLDFIETNPAARLD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	247/498 (50%)
FRS2	NP_116631.1	PTZ00326	1..486	CDD:240361	243/486 (50%)