Protein Alignment alpha-PheRS and FRS2

DIOPT Version :9

• Sequence 1: NP_572448.1
• Gene: alpha-PheRS / 31740
• FlyBaseID: FBgn0030007
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_116631.1
• Gene: FRS2 / 850522
• SGDID: S000001872
• Length: 503
• Species: Saccharomyces cerevisiae
• Alignment Length: 500
• Identity: 249/500 - (49%)
• Similarity: 324/500 - (64%)
• Gaps: 23/500 - (4%)

  Fly    13 LETTDKADTLD-----LAALFAEDHQKIVGSLKSIQAHG--ELVTAETVTHKSLGLTDEGRAVVE 70
            ||...|.|.||     ||.......|.::.:|.|::||.  |....:|||:   .||.||..::.
Yeast     6 LEILKKLDELDEIKSTLATFPQHGSQDVLSALNSLKAHNKLEFSKVDTVTY---DLTKEGAQILN 67

  Fly    71 NGSHEALVYDLVPPEGIAQA--ALMAAGGANAKVGFSKAMSHGWILVDKS----VTPPLVRRKVD 129
            .||:|..:..|:...|..|.  .:...|....|||.::|..:|||..:.|    ::..|....::
Yeast    68 EGSYEIKLVKLIQELGQLQIKDVMSKLGPQVGKVGQARAFKNGWIAKNASNELELSAKLQNTDLN 132

  Fly   130 TITDVVRNQLQQVALGKG-DQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTV 193
            .:||..::.|.|:..... |.:.||.:.|.|||||:.:.....|.:.:||||:|.|||||||||.
Yeast   133 ELTDETQSILAQIKNNSHLDSIDAKILNDLKKRKLIAQGKITDFNVTKGPEFSTDLTKLETDLTS 197

  Fly   194 EMLANGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNF 258
            :|::...:..||||.|||::.|...:.|.||||.|||.||||||..|||:|||:|.|||:.||||
Yeast   198 DMVSTNAYKDLKFKPYNFNSQGVQISSGALHPLNKVREEFRQIFFSMGFTEMPSNQYVETGFWNF 262

  Fly   259 DALYQPQQHPARDAHDTFFVNHPAKSHKFPQD--YLERVKKVHSVGGYGSKGYGYDWKLEEAQKN 321
            ||||.||||||||..|||::..|..: ..|.|  |::.:|.||..|.:||.||.|:||.||.||.
Yeast   263 DALYVPQQHPARDLQDTFYIKDPLTA-DLPDDKTYMDNIKAVHEQGRFGSIGYRYNWKPEECQKL 326

  Fly   322 LLRTHTTAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGD 386
            :||||:||:|||||:.||...   |..:.||||:|||||.:||||||||||||||:||..:||||
Yeast   327 VLRTHSTAISARMLHDLAKDP---KPTRLFSIDRVFRNEAVDATHLAEFHQVEGVLADYNITLGD 388

  Fly   387 LIGTLYEFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPEN 451
            ||..:.|||.::|:|.|.|||.||||||||||||.:|.||.||:|:||||:||||||..||||::
Yeast   389 LIKFMEEFFERMGVTGLRFKPTYNPYTEPSMEIFSWHEGLQKWVEIGNSGMFRPEMLESMGLPKD 453

  Fly   452 VNVIAWGLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            :.|:.|||||||||||||.:.|||:|:|.||.|..:|..|..|||
Yeast   454 LRVLGWGLSLERPTMIKYKVQNIRELLGHKVSLDFIETNPAARLD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	247/498 (50%)
		PheRS_alpha_core	224..483	CDD:238277	166/260 (64%)
FRS2	NP_116631.1	PTZ00326	1..486	CDD:240361	243/486 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344505
Domainoid	1	1.000	356	1.000	Domainoid score	I133
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3280
Inparanoid	1	1.050	461	1.000	Inparanoid score	I237
Isobase	1	0.950	-	0	Normalized mean entropy	S460
OMA	1	1.010	-	-		QHG53816
OrthoFinder	1	1.000	-	-		FOG0004743
OrthoInspector	1	1.000	-	-		oto100075
orthoMCL	1	0.900	-	-		OOG6_100669
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1437
SonicParanoid	1	1.000	-	-		X2815
TreeFam	1	0.960	-	-
	16	15.740