DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-PheRS and fars2

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001099064.1	Gene:	fars2 / 793097	ZFINID:	ZDB-GENE-070928-38	Length:	449	Species:	Danio rerio

Alignment Length:	304	Identity:	72/304 - (23%)
Similarity:	111/304 - (36%)	Gaps:	101/304 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RGHLHPLLKVRTEFRQIFLE--MG------FSEMPTNNYVESSFWNFDALYQPQQHPARDAHDTF 276
            |.| |||..::...:..|..  :|      ||.......|.:...|||:|..|..||:....:.:
Zfish    78 RPH-HPLWLIKERIKDHFYRSYVGRTGNPIFSVHDNLRPVVTVEQNFDSLLIPADHPSCKKGENY 141

  Fly   277 FVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHTTAVSARMLYKLANQ 341
            ::|   ::|                                    :||.||:|....::
Zfish   142 YLN---RTH------------------------------------MLRAHTSAHQKELV------ 161

  Fly   342 EGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGV--------IADV----GLTLGDLIG----- 389
            ..|...  :.....|:|.:.:|::|...|||:|||        .|.|    .|:|.:..|
Zfish   162 RSGLDC--FLLAGDVYRRDEVDSSHYPVFHQMEGVRLFSNHELFAGVENGEDLSLFERGGRRTPQ 224

  Fly   390 ----------TLYEFFRKLGITQL-----------EFKPAYNPYTEPSMEIFCYHPGLAKWIEVG 433
                      .|.||..|..:|:|           .:...|.|:|.||.|:..:..|  .|:||.
Zfish   225 KQETHTLEAVKLLEFDLKRALTRLVRHLFGEDLEIRWVDCYFPFTHPSFEMEVFFQG--DWMEVL 287

  Fly   434 NSGVFRPEMLLPMGLPENVNVIAW--GLSLERPTMIKYGINNIR 475
            ..||...|::...|..   |.:.|  ||.|||..|:.:||.:||
Zfish   288 GCGVMEQELVRSAGAD---NKMGWAFGLGLERLAMVLFGIPDIR 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	72/304 (24%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	70/300 (23%)
fars2	NP_001099064.1	PLN02788	54..448	CDD:215422	72/304 (24%)
		PheRS_alpha_core	81..336	CDD:238277	70/300 (23%)
		FDX-ACB	356..448	CDD:214893
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910