DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-PheRS and Farsa

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_001019408.1	Gene:	Farsa / 288917	RGDID:	1310314	Length:	508	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	311/492 - (63%)
Similarity:	382/492 - (77%)	Gaps:	5/492 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ERILQHLETTDKA-DTLDLAALFAEDHQKIVGSLKSIQAHGELVTAETVTHKSLGLTDEGRAVVE 70
            |::|:.||..|.. |:.:||.....:||.:||::||:||.||::.||..:.|...||.||..:..
  Rat     8 EQLLRRLEVADGGLDSAELATQLGVEHQAVVGAVKSLQALGEVIEAELRSTKCWELTTEGEEIAR 72

  Fly    71 NGSHEALVYDLVPPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTP-PLVRRKVDTITDV 134
            .|||||.|:..:|.||:.|:.||..  .:.|||||||||:.||.||||... |.|.|.||:|.|.
  Rat    73 EGSHEARVFRSIPLEGLVQSELMQL--PSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSIEDE 135

  Fly   135 VRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTVEMLANG 199
            |:.:||||..|:.::|..||..:.:|||||.|...|::.:::|..|:|:::|.|.:|:.||:::|
  Rat   136 VQRRLQQVQAGQAEKLAEKERNELRKRKLLTEVILKTYWVSKGKGFSTSVSKQEAELSPEMISSG 200

  Fly   200 LWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNFDALYQP 264
            .|....||.|||.|.|..|..||||||||||::||||||||||:||||:|::||||||||||:||
  Rat   201 SWRDRPFKPYNFSARGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQP 265

  Fly   265 QQHPARDAHDTFFVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHTTA 329
            |||||||.|||||:..||::.:.|.||::|||:.||.|||||:||.|.||||||:||||||||||
  Rat   266 QQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYTWKLEEARKNLLRTHTTA 330

  Fly   330 VSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGDLIGTLYEF 394
            .|||.||:|| |:..|..|||||||:|||||||||||||||||:||||||.|||||.|:|.|.||
  Rat   331 ASARALYRLA-QKKPFTPAKYFSIDRVFRNETLDATHLAEFHQIEGVIADHGLTLGHLMGVLREF 394

  Fly   395 FRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPENVNVIAWGL 459
            |.|||||||.||||||||||||||:|.||.||.||:||||||||||||||||||||||:||||||
  Rat   395 FTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGL 459

  Fly   460 SLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            ||||||||||||||||:|||.||:|:||.:.|:||||
  Rat   460 SLERPTMIKYGINNIRELVGHKVNLQMVYDSPVCRLD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	309/490 (63%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	206/258 (80%)
Farsa	NP_001019408.1	PLN02853	8..497	CDD:215458	311/492 (63%)
		HTH_11	8..54	CDD:285479	18/45 (40%)
		tRNA-synt_2d	209..482	CDD:279717	214/273 (78%)
		L-phenylalanine binding. /evidence=ECO:0000250\|UniProtKB:Q9Y285	372..374		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344424
Domainoid	1	1.000	453	1.000	Domainoid score	I485
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3280
Inparanoid	1	1.050	621	1.000	Inparanoid score	I844
OMA	1	1.010	-	-		QHG53816
OrthoDB	1	1.010	-	-		D197408at33208
OrthoFinder	1	1.000	-	-		FOG0004743
OrthoInspector	1	1.000	-	-		oto98161
orthoMCL	1	0.900	-	-		OOG6_100669
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2815
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770