DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-PheRS and frs2

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_594078.1	Gene:	frs2 / 2543647	PomBaseID:	SPAC3G9.06	Length:	499	Species:	Schizosaccharomyces pombe

Alignment Length:	441	Identity:	245/441 - (55%)
Similarity:	300/441 - (68%)	Gaps:	13/441 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LTDEGRAVVENGSHEALVYDLV--PPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTPPL 123
            ||.||..:..||||||.||:.:  ...|:....|....|.:|.:|..:|...|||..|..   .|
pombe    64 LTAEGENICANGSHEAKVYNEICASMSGLNIGELKKKLGNSAGIGQGRAFKLGWIKKDGD---KL 125

  Fly   124 VRRKVDTITDVVRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLE 188
            | :..|:|||.....|.::. ..|....:|.:.|.|||||::......|.|.:||.|:..:.||.
pombe   126 V-KNTDSITDETPKVLSEIK-EHGTISDSKTLTDLKKRKLVERNKIMYFSLRKGPNFSLQIEKLN 188

  Fly   189 TDLTVEMLANGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVES 253
            ||||.||:.:..|:..|||:|||.|.|.||..|.||||:|||.|||:.|.|:||.||||||:|||
pombe   189 TDLTAEMITSRSWESAKFKSYNFAAEGIPPAGGCLHPLMKVREEFRKFFFELGFEEMPTNNFVES 253

  Fly   254 SFWNFDALYQPQQHPARDAHDTFFVNHPAKSHKFPQ-DYLERVKKVHSVGGYGSKGYGY--DWKL 315
            .|||||||:.||||.||||.||||:..||.:.|.|. :|:.|||..|..|| .:||.||  .:.|
pombe   254 GFWNFDALFVPQQHSARDAQDTFFLKVPASTDKLPDPEYVARVKATHENGG-ETKGIGYRAPFSL 317

  Fly   316 EEAQKNLLRTHTTAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADV 380
            ||.:|.:||||||||||.||||||  :.||..|||||||:||||||:|||||||||||||||.|.
pombe   318 EETRKLVLRTHTTAVSANMLYKLA--QNGFHPAKYFSIDRVFRNETVDATHLAEFHQVEGVICDR 380

  Fly   381 GLTLGDLIGTLYEFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLP 445
            .:|||||||.|..||.|:.:..|.||||||||||||:|:|.||..|.||:||||||:||||||.|
pombe   381 NITLGDLIGFLEVFFGKMNVKNLRFKPAYNPYTEPSLEVFSYHEKLGKWVEVGNSGMFRPEMLEP 445

  Fly   446 MGLPENVNVIAWGLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            ||||::|..:.:|||||||||||||:.:||.|:||||:|.::|..|..|||
pombe   446 MGLPKDVRCLGFGLSLERPTMIKYGVADIRQLIGPKVNLDLIEASPAVRLD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	243/439 (55%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	175/261 (67%)
frs2	NP_594078.1	PLN02853	11..496	CDD:215458	243/439 (55%)
frs2	NP_594078.1	tRNA-synt_2d	208..482	CDD:279717	183/276 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	371	1.000	Domainoid score	I140
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3280
Inparanoid	1	1.050	460	1.000	Inparanoid score	I283
OMA	1	1.010	-	-		QHG53816
OrthoFinder	1	1.000	-	-		FOG0004743
OrthoInspector	1	1.000	-	-		oto101808
orthoMCL	1	0.900	-	-		OOG6_100669
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1437
SonicParanoid	1	1.000	-	-		X2815
TreeFam	1	0.960	-	-
	14	13.860