DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-PheRS and FARSA

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_004452.1	Gene:	FARSA / 2193	HGNCID:	3592	Length:	508	Species:	Homo sapiens

Alignment Length:	494	Identity:	310/494 - (62%)
Similarity:	388/494 - (78%)	Gaps:	5/494 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LTERILQHLETTDKA-DTLDLAALFAEDHQKIVGSLKSIQAHGELVTAETVTHKSLGLTDEGRAV 68
            :.|.:|:.||.:|.. |:.:|||....:||.:||::||:||.||::.||..:.|...||.||..:
Human     6 VAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEI 70

  Fly    69 VENGSHEALVYDLVPPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTP-PLVRRKVDTIT 132
            ...|||||.|:..:||||:||:.||..  .:.|||||||||:.||.||||... |.|.|.||::.
Human    71 AREGSHEARVFRSIPPEGLAQSELMRL--PSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSME 133

  Fly   133 DVVRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTVEMLA 197
            |.|:.:||.|..|:.::|..||.::.:|||||.|.|.|::.:::|..|:|:::|.||:|:.||::
Human   134 DEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMIS 198

  Fly   198 NGLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNFDALY 262
            :|.|....||.|||.|.|..|..||||||||||::||||||||||:||||:|::||||||||||:
Human   199 SGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALF 263

  Fly   263 QPQQHPARDAHDTFFVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHT 327
            |||||||||.|||||:..||::.:.|.||::|||:.||.|||||:||.|:|||:||:||||||||
Human   264 QPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHT 328

  Fly   328 TAVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGDLIGTLY 392
            |:.|||.||:|| |:..|...||||||:|||||||||||||||||:|||:||.|||||.|:|.|.
Human   329 TSASARALYRLA-QKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLR 392

  Fly   393 EFFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPENVNVIAW 457
            |||.|||||||.||||||||||||||:|.||.||.||:||||||||||||||||||||||:||||
Human   393 EFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAW 457

  Fly   458 GLSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            ||||||||||||||||||:|||.||:|:||.:.|:||||
Human   458 GLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	308/492 (63%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	202/258 (78%)
FARSA	NP_004452.1	PTZ00326	1..484	CDD:240361	302/480 (63%)
FARSA	NP_004452.1	L-phenylalanine binding. /evidence=ECO:0000269\|PubMed:20223217, ECO:0007744\|PDB:3L4G	372..374		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150896
Domainoid	1	1.000	448	1.000	Domainoid score	I520
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3280
Inparanoid	1	1.050	622	1.000	Inparanoid score	I878
Isobase	1	0.950	-	0	Normalized mean entropy	S460
OMA	1	1.010	-	-		QHG53816
OrthoDB	1	1.010	-	-		D197408at33208
OrthoFinder	1	1.000	-	-		FOG0004743
OrthoInspector	1	1.000	-	-		oto91068
orthoMCL	1	0.900	-	-		OOG6_100669
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720