DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-PheRS and fars-1

DIOPT Version :9

Sequence 1:	NP_572448.1	Gene:	alpha-PheRS / 31740	FlyBaseID:	FBgn0030007	Length:	498	Species:	Drosophila melanogaster
Sequence 2:	NP_491792.1	Gene:	fars-1 / 172311	WormBaseID:	WBGene00001497	Length:	552	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	298/493 - (60%)
Similarity:	367/493 - (74%)	Gaps:	9/493 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DLTERILQHLETTDKADTLDLAALFAEDHQKIVGSLKSIQAHGELVTAETVTHKSLGLTDEGRAV 68
            :|.::||..|:.:::.:::.||..:..||||::|::||:.|:..::|.:.||.|.|.||:||...
Worm    68 NLPQQILDFLQESNEFNSIQLAQQWNLDHQKVIGAIKSLLANEGVLTTKDVTEKRLELTNEGVQF 132

  Fly    69 VENGSHEALVYDLVPPEGIAQAALMAAGGANAKVGFSKAMSHGWILVDKSVTPPLVRRKVDTITD 133
            ...||.|.||::.|..:|.|||.:...  ...|:|.:|||...|:.|||.    .|.|:...:||
Worm   133 ANEGSPEYLVFEFVGTDGAAQADIQKK--PFGKIGMAKAMQFKWVSVDKG----RVVRQATEVTD 191

  Fly   134 VVRNQLQQVALGKGDQLPAKEVADFKKRKLLQETTTKSFVLARGPEFATTLTKLETDLTVEMLAN 198
            ..|.||:.:.:|..| :...|..:.|||||:.|...|:.|:::|..|.|:|.|.|.|||.||:|:
Worm   192 STRKQLESLRIGSSD-VSENEKKELKKRKLISEVNIKALVVSKGTSFTTSLAKQEADLTPEMIAS 255

  Fly   199 GLWDQLKFKAYNFDALGAPPTRGHLHPLLKVRTEFRQIFLEMGFSEMPTNNYVESSFWNFDALYQ 263
            |.|..::||.||||:||..|:.||||||:|||:||||||..||||||.||.||||||||||||:|
Worm   256 GSWKDMQFKKYNFDSLGVVPSSGHLHPLMKVRSEFRQIFFSMGFSEMATNRYVESSFWNFDALFQ 320

  Fly   264 PQQHPARDAHDTFFVNHPAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHTT 328
            |||||||||||||||:.||.|.|||:|||||||.|||.|||||.||.||||:||||||:||||||
Worm   321 PQQHPARDAHDTFFVSDPAISTKFPEDYLERVKTVHSKGGYGSAGYNYDWKIEEAQKNVLRTHTT 385

  Fly   329 AVSARMLYKLANQEGGFKAAKYFSIDKVFRNETLDATHLAEFHQVEGVIADVGLTLGDLIGTLYE 393
            |||||.||:||.:  ||:.:|.||||:|||||||||||||||||||||||:..|:|..|||...|
Worm   386 AVSARQLYQLAQE--GFRPSKLFSIDRVFRNETLDATHLAEFHQVEGVIAEKNLSLAHLIGIFTE 448

  Fly   394 FFRKLGITQLEFKPAYNPYTEPSMEIFCYHPGLAKWIEVGNSGVFRPEMLLPMGLPENVNVIAWG 458
            ||:|||||.|.|||.||||||||||||.||.||.||:|:||||:||||||||||||.:|||..:|
Worm   449 FFKKLGITNLRFKPTYNPYTEPSMEIFAYHQGLTKWVEIGNSGMFRPEMLLPMGLPADVNVAGYG 513

  Fly   459 LSLERPTMIKYGINNIRDLVGPKVDLKMVEEGPICRLD 496
            |||||||||||||||||||.|.|:||.:|...||||||
Worm   514 LSLERPTMIKYGINNIRDLFGSKIDLNVVYNNPICRLD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	296/491 (60%)
alpha-PheRS	NP_572448.1	PheRS_alpha_core	224..483	CDD:238277	203/258 (79%)
fars-1	NP_491792.1	GST_C_family	<7..55	CDD:383119
fars-1	NP_491792.1	PTZ00326	65..539	CDD:240361	289/479 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161746
Domainoid	1	1.000	450	1.000	Domainoid score	I263
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3280
Inparanoid	1	1.050	596	1.000	Inparanoid score	I523
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53816
OrthoDB	1	1.010	-	-		D197408at33208
OrthoFinder	1	1.000	-	-		FOG0004743
OrthoInspector	1	1.000	-	-		oto19742
orthoMCL	1	0.900	-	-		OOG6_100669
Panther	1	1.100	-	-	LDO	PTHR11538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1437
SonicParanoid	1	1.000	-	-		X2815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940