Protein Alignment alpha-PheRS and FARS2

DIOPT Version :9

• Sequence 1: NP_572448.1
• Gene: alpha-PheRS / 31740
• FlyBaseID: FBgn0030007
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001305801.1
• Gene: FARS2 / 10667
• HGNCID: 21062
• Length: 451
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 72/298 - (24%)
• Similarity: 114/298 - (38%)
• Gaps: 97/298 - (32%)

  Fly   224 HPLLKVRTEFRQIFLE--MG------FSEMPTNNYVESSFWNFDALYQPQQHPARDAHDTFFVNH 280
            |||..::...::.|.:  :|      ||.....:.|.:::.|||:|..|..||:|...|.:::|
Human    84 HPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLN- 147

  Fly   281 PAKSHKFPQDYLERVKKVHSVGGYGSKGYGYDWKLEEAQKNLLRTHTTAVSARMLYKLANQEGGF 345
              ::|                                    :||.||:|....:|:      .|.
Human   148 --RTH------------------------------------MLRAHTSAHQWDLLH------AGL 168

  Fly   346 KAAKYFSIDKVFRNETLDATHLAEFHQVEGV-----------IAD-------------------- 379
            .|  :..:..|:|.:.:|:.|...|||:|.|           |.|
Human   169 DA--FLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETH 231

  Fly   380 ----VGLTLGDLIGTLYEFFRKLGITQLEFK--PAYNPYTEPSMEI-FCYHPGLAKWIEVGNSGV 437
                |.|...||..||......|...:||.:  ..|.|:|.||.|: ..:|   .:|:||...||
Human   232 TMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFH---GEWLEVLGCGV 293

  Fly   438 FRPEMLLPMGLPENVNVIAWGLSLERPTMIKYGINNIR 475
            ...:::...|..:.:. .|:||.|||..||.|.|.:||
Human   294 MEQQLVNSAGAQDRIG-WAFGLGLERLAMILYDIPDIR 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-PheRS	NP_572448.1	PLN02853	4..496	CDD:215458	72/298 (24%)
		PheRS_alpha_core	224..483	CDD:238277	72/298 (24%)
FARS2	NP_001305801.1	PLN02788	29..450	CDD:215422	72/298 (24%)
		Substrate binding	157..160		1/2 (50%)
		Substrate binding	186..188		0/1 (0%)
		Substrate binding	193..195		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0016
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810