DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HNF4G and Hnf4

DIOPT Version :9

Sequence 1:	NP_004124.5	Gene:	HNF4G / 3174	HGNCID:	5026	Length:	455	Species:	Homo sapiens
Sequence 2:	NP_723413.1	Gene:	Hnf4 / 44544	FlyBaseID:	FBgn0004914	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	249/502 - (49%)
Similarity:	315/502 - (62%)	Gaps:	97/502 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    37 NSSDSSAPETSMNTTDNGVN---------------CLCAICGDRATGKHYGASSCDGCKGFFRRS 86
            |::...:|..:::.:.:|.|               .:||||||||||||||||||||||||||||
  Fly   133 NNNSMFSPNNNLSGSGSGTNSSQQQLQQQQQQQSPTVCAICGDRATGKHYGASSCDGCKGFFRRS 197

Human    87 IRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFD----GSN 147
            :||:|.|:|||:|.||||||||||||||||||||:||||||||||||||||.||::.|    |:.
  Fly   198 VRKNHQYTCRFARNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRISCRRTSNDDPDPGNG 262

Human   148 IPSINTLAQAEVRSRQISVSS---PGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCE 209
            : |:.:|.:||..|||....:   |..:.|::.|:.|||.|||||||||||.||||||.||||.|
  Fly   263 L-SVISLVKAENESRQSKAGAAMEPNINEDLSNKQFASINDVCESMKQQLLTLVEWAKQIPAFNE 326

Human   210 LPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRN------SCEVEISRVANRVLD 268
            |.|||||||||||||||||||.::|||..||:|||.||.||.|:      |..::|||:..|::|
  Fly   327 LQLDDQVALLRAHAGEHLLLGLSRRSMHLKDVLLLSNNCVITRHCPDPLVSPNLDISRIGARIID 391

Human   269 ELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFG 333
            |||...:::.|||.|:||:||:|||||:||||::|.:||::|.|:...|||||:||||:||||||
  Fly   392 ELVTVMKDVGIDDTEFACIKALVFFDPNAKGLNEPHRIKSLRHQILNNLEDYISDRQYESRGRFG 456

Human   334 ELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGG----------ASNDGSHLHHPMH 388
            |:||:||.||||||||||||||.|:||:..||:|||||||||          ..|..:....|.|
  Fly   457 EILLILPVLQSITWQMIEQIQFAKIFGVAHIDSLLQEMLLGGELADNPLPLSPPNQSNDYQSPTH 521

Human   389 P---------HLSQDPLTGQTILLGP-----------MSTLVHADQI------------------ 415
            .         :.|.|.|....   ||           :..|:.|:..
  Fly   522 TGNMEGGNQVNSSLDSLATSG---GPGSHSLDLEVQHIQALIEANSADDSFRAYAASTAAAAAAA 583

Human   416 -----STPETPLP---SPPQGSGQEQYKIAANQASVISHQHLSKQKQ 454
                 |.|.:..|   |||..|.:.|::         ..||.:.|:|
  Fly   584 VSSSSSAPASVAPASISPPLNSPKSQHQ---------HQQHATHQQQ 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNF4G	NP_004124.5	NR_DBD_HNF4A	59..134	CDD:143518	67/74 (91%)
HNF4G	NP_004124.5	NR_LBD_HNF4_like	150..371	CDD:132729	141/229 (62%)
Hnf4	NP_723413.1	NR_DBD_HNF4A	170..245	CDD:143518	67/74 (91%)
Hnf4	NP_723413.1	NR_LBD_HNF4_like	264..494	CDD:132729	141/229 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I2052
eggNOG	1	0.900	-	-		E1_KOG4215
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	451	1.000	Inparanoid score	I1610
Isobase	1	0.950	-	0	Normalized mean entropy	S3544
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003424
OrthoInspector	1	1.000	-	-		otm42307
orthoMCL	1	0.900	-	-		OOG6_105157
Panther	1	1.100	-	-	LDO	PTHR24083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2679
SonicParanoid	1	1.000	-	-		X1958
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.800