DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and Smad7

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_110485.1	Gene:	Smad7 / 81516	RGDID:	69314	Length:	426	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	118/458 - (25%)
Similarity:	180/458 - (39%)	Gaps:	152/458 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KAVKNLVKKIKKNSQLEELERAISTQ-NCQTRCVTVP-----RSKP-APAGEHLRK-----GLPH 83
            ||:.:.|.|..|..|||.|.:|:.:: ..:|.|:.:|     |..| |||.....:     .||
  Rat    93 KALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLP- 156

  Fly    84 VIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDY 148
            ::.|:::|||||:..:|:|.|..||....:..|.:|.||:|     ||.|.....|.||.|  .|
  Rat   157 LLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHH-----LSRLCELESPPPPYS--RY 214

  Fly   149 PLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSS 213
            |:|                    .|.|             .:....:.|::...||
  Rat   215 PMD--------------------FLKP-------------TADCPDAVPSSDETGG--------- 237

  Fly   214 SSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRLTP 278
                                                |....||.:|:....::|.|.
  Rat   238 ------------------------------------TNYLAPGGLSDSQLLLEPGDR-------- 258

  Fly   279 PADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEV 343
                        :.||.::|:|..||||..:...:||:  |.|.|......||||.|::.|::::
  Rat   259 ------------SHWCVVAYWEEKTRVGRLYCVQEPSL--DIFYDLPQGNGFCLGQLNSDNKSQL 309

  Fly   344 VEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQS---PNCNQRYGWHPATVCKIPPGCNLKIF- 404
            |::.|..||.|::|......|:....|...||::|   .|.:.|    ...|.|:.||.::|.|
  Rat   310 VQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSR----TLLVHKVFPGFSIKAFD 370

  Fly   405 ----------NNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIEL 459
                      |:.||    .|....||          |:::|||||||..|.||.::|.|||:|:
  Rat   371 YEKAYSLQRPNDHEF----MQQPWTGF----------TVQISFVKGWGQCYTRQFISSCPCWLEV 421

  Fly   460 HLN 462
            ..|
  Rat   422 IFN 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	36/110 (33%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	61/192 (32%)
Smad7	NP_110485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40
		MH1_SMAD_7	60..205	CDD:199818	39/117 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..88
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		5/10 (50%)
		PY-motif. /evidence=ECO:0000250	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	62/209 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810