DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and smad10a

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001352568.1	Gene:	smad10a / 560317	ZFINID:	ZDB-GENE-060503-248	Length:	581	Species:	Danio rerio

Alignment Length:	584	Identity:	187/584 - (32%)
Similarity:	278/584 - (47%)	Gaps:	142/584 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIK-KNSQLEELERAISTQNCQ-TRCVTVPRSKP 70
            :|..|:..::|.|:   || ::::|:::||||:| |..:|:.|..||:|.... ::|||:.|:..
Zfish    15 IVHSLMCHRQGGEN---EG-FAKRAIESLVKKLKEKKDELDSLITAITTNGVHPSKCVTIQRTLD 75

  Fly    71 APAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVP 135
            .......|||.|||||.||||||||. :||||.:..|:|||.|:.:.:|:|||||:::....:|.
Zfish    76 GRLQVAGRKGFPHVIYARLWRWPDLH-KNELKHVKFCQYAFDLKYDNVCVNPYHYERVVSPGIVG 139

  Fly   136 KSLPT------------PPDSIVDYPLDNHTHQ---------IPNNTDYNAAIIRSASLSPPQY- 178
            .||..            |...::.   :.::|.         :|...|:..|:    .|.||.:
Zfish   140 LSLQNTETHLSSGRCLGPTGRLIK---EEYSHDCIQMDVPPGLPPQQDHQGAM----KLPPPDHY 197

  Fly   179 ------MELGGAG-----PVSVSSSASSTPATAAG------GGGG-------------------P 207
                  ::|...|     ||::.|:...:| ||:|      ||.|                   |
Zfish   198 GQPLPPLQLPSEGPRAPPPVTLYSNMPLSP-TASGSMMPMQGGHGEGLLQIASPQGQVMTPTPPP 261

  Fly   208 SSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDN-- 270
            |:.:..........|....|..:..:..||:.     .|...|.|   |..:....|:.|..|
Zfish   262 STPTHGPPQTPVPPQPPPNQNGYNSSKHSQTQ-----GSFHTTWT---GSSTASYTPVGPQQNGR 318

  Fly   271 --------------MNMSRLTPPADAAPVMYHE-PAFWCSISYYELNTRVGETFH--ASQPSITV 318
                          .:.|...||    ||..|. |.|||||||:|::.:|||.|.  :|.|.:|:
Zfish   319 GHQPPLHHPHFWSQHHSSASFPP----PVSNHPGPEFWCSISYFEMDVQVGEMFKVLSSCPVVTI 379

  Fly   319 DGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIG-GEVFAECLSDSSIFVQSPNCN 382
            ||:.|||..:|||||.||||:|.:..|:.|.||||||:|...| |:|:..|:||.::||||...:
Zfish   380 DGYVDPSGGDRFCLGQLSNVHRTDASERARLHIGKGVQLECRGEGDVWMRCMSDHAVFVQSYYLD 444

  Fly   383 QRYGWHPA-TVCKIPPGCNLKIFNNQE-----------------------------------FAA 411
            :..|..|. .|.||.||..:|:|:.::                                   .|.
Zfish   445 REAGRAPGDAVHKIYPGAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP 509

  Fly   412 LLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQM 475
            .:|.|.:.|. .|..|.|:|.:|:|||||||.:|.||::..||||:|:||:..||.||.||..|
Zfish   510 AVSLSAAAGI-GVDDLRRLCILRLSFVKGWGPDYPRQSIKHTPCWVEVHLHRALQLLDEVLHTM 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	53/123 (43%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	93/229 (41%)
smad10a	NP_001352568.1	MH1_SMAD_4	10..134	CDD:199816	53/123 (43%)
smad10a	NP_001352568.1	MH2_SMAD_4	349..570	CDD:199823	90/221 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810