DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and smad4a

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_017213465.1	Gene:	smad4a / 559111	ZFINID:	ZDB-GENE-990603-8	Length:	548	Species:	Danio rerio

Alignment Length:	549	Identity:	187/549 - (34%)
Similarity:	271/549 - (49%)	Gaps:	106/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIK-KNSQLEELERAISTQNCQ-TRCVTVPRSKP 70
            :|..|:..::|.|..:    ::::|:::||||:| |..:|:.|..||:|.... ::|||:.|:..
Zfish    16 IVHSLMCHRQGGESET----FAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLD 76

  Fly    71 APAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKK-----IEL 130
            .......|||.|||||.||||||||. :||||.:.:|::||.|:.:.:|:|||||::     |:|
Zfish    77 GRLQVAGRKGFPHVIYARLWRWPDLH-KNELKHVKYCQFAFDLKCDSVCVNPYHYERVVSPGIDL 140

  Fly   131 SILV-----PKSLPTPPDSIVDYPLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVS 190
            |.|.     |..|....:...|.|     ..:|:...:...|     ..||..         :|:
Zfish   141 SGLTLSGSGPSGLMVKDEYDYDGP-----PSLPSTEGHMQTI-----QHPPSR---------AVT 186

  Fly   191 SSASSTPATAAGGGGGPSSSSSS-SSSAASAYQQQQQQLSFGQNMDSQSSVLS-VGSSIPNTGTP 253
            ....||||......|..|:|||: ||.|..:..|....||...:.||...:.| .|......|.|
Zfish   187 QEPFSTPALLPPAEGSSSASSSAFSSIAVGSTTQPGSVLSGSHSSDSLLQIASGTGQGSQQNGFP 251

  Fly   254 PPGYMSEDGDP-------------IDPNDNMNMSRLTPPADAA-------------PVMYH--EP 290
            |....:...:|             :..:.|.::....|.|..|             |:..|  .|
Zfish   252 PGQTSTYHHNPTSSWSRNSNFTPSVPHHQNGHLQHHPPMAHPAHYWPVHNEIAFQPPISNHPAAP 316

  Fly   291 AFWCSISYYELNTRVGETFH--ASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGK 353
            .:||||:|:|::.:|||||.  :|.|.:||||:.|||..:|||||.||||:|.|.:|:.|.||||
Zfish   317 EYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGK 381

  Fly   354 GVRLYYIG-GEVFAECLSDSSIFVQSPNCNQRYGWHPA-TVCKIPPGCNLKIFNNQE-------- 408
            ||:|...| |:|:..||||.::||||...::..|..|. .|.||.|...:|:|:.::
Zfish   382 GVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQ 446

  Fly   409 ---------------------------FAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYR 446
                                       .|..:|.|.:.|. .|..|.|:|.:|||||||||.:|.
Zfish   447 AATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGI-GVDDLRRLCILRMSFVKGWGPDYP 510

  Fly   447 RQTVTSTPCWIELHLNGPLQWLDRVLTQM 475
            ||::..||||||:||:..||.||.||..|
Zfish   511 RQSIKETPCWIEIHLHRALQLLDEVLHTM 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	51/128 (40%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	95/230 (41%)
smad4a	XP_017213465.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810