Protein Alignment Smox and Smad4

DIOPT Version :9

• Sequence 1: NP_001285006.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_062148.1
• Gene: Smad4 / 50554
• RGDID: 3033
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 188/545 - (34%)
• Similarity: 275/545 - (50%)
• Gaps: 97/545 - (17%)

  Fly     8 VVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIK-KNSQLEELERAISTQNCQ-TRCVTVPRSKP 70
            :|..|:..::|.|..:    ::::|:::||||:| |..:|:.|..||:|.... ::|||:.|:..
  Rat    19 IVHSLMCHRQGGESET----FAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLD 79

  Fly    71 APAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKK-----IEL 130
            .......|||.|||||.||||||||. :||||.:.:|:|||.|:.:.:|:|||||::     |:|
  Rat    80 GRLQVAGRKGFPHVIYARLWRWPDLH-KNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDL 143

  Fly   131 SILVPKSLPTPPDSIV------DY------PLDNHTHQI----PNNTDYNAAIIRSASLSPPQYM 179
            |.|..:| ..||..:|      |:      |.:.|:.|.    |:|..........|.|:|.:..
  Rat   144 SGLTLQS-NAPPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPSESN 207

  Fly   180 ELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVG 244
            ........::..:::|.||:...|     |.|......||..|..|||..|    .:|.:.....
  Rat   208 ATSTTNFPNIPVASTSQPASILAG-----SHSEGLLQIASGPQPGQQQNGF----TAQPATYHHN 263

  Fly   245 SSIPNTGTPPPGYM-----SEDG-----DPIDPNDN-----MNMSRLTPPADAAPVMYHEPAFWC 294
            |:...||:....|.     .::|     .|:.|:..     .|.....||....|.    |.:||
  Rat   264 STTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPA----PEYWC 324

  Fly   295 SISYYELNTRVGETFH--ASQPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRL 357
            ||:|:|::.:|||||.  :|.|.:||||:.|||..:|||||.||||:|.|.:|:.|.||||||:|
  Rat   325 SIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQL 389

  Fly   358 YYIG-GEVFAECLSDSSIFVQSPNCNQRYGWHPA-TVCKIPPGCNLKIFNNQE------------ 408
            ...| |:|:..||||.::||||...::..|..|. .|.||.|...:|:|:.::
  Rat   390 ECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATA 454

  Fly   409 -----------------------FAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTV 450
                                   .|..:|.|.:.|. .|..|.|:|.:|||||||||.:|.||::
  Rat   455 QAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGI-GVDDLRRLCILRMSFVKGWGPDYPRQSI 518

  Fly   451 TSTPCWIELHLNGPLQWLDRVLTQM 475
            ..||||||:||:..||.||.||..|
  Rat   519 KETPCWIEIHLHRALQLLDEVLHTM 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	52/128 (41%)
		MH2_SMAD_2_3	285..475	CDD:199826	94/228 (41%)
Smad4	NP_062148.1	Mediates interaction with ZBTB7A. /evidence=ECO:0000250|UniProtKB:Q13485	1..322		94/321 (29%)
		MH1_SMAD_4	14..138	CDD:199816	51/123 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..193		5/25 (20%)
		SAD	275..320		8/48 (17%)
		MH2_SMAD_4	320..541	CDD:199823	93/221 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910