Protein Alignment Smox and SMAD7

DIOPT Version :10

• Sequence 1: NP_511079.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_005895.1
• Gene: SMAD7 / 4092
• HGNCID: 6773
• Length: 426
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 120/458 - (26%)
• Similarity: 182/458 - (39%)
• Gaps: 152/458 - (33%)

  Fly    31 KAVKNLVKKIKKNSQLEELERAISTQ-NCQTRCVTVP-----RSKP-APAGEHLRK-----GLPH 83
            ||:.:.|.|..|..|||.|.:|:.:: ..:|.|:.:|     |..| ||||....:     .||
Human    93 KALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLP- 156

  Fly    84 VIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDY 148
            ::.|:::|||||:..:|:|.|..||....:..|.:|.||:|     ||.|.....|.||.|  .|
Human   157 LLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHH-----LSRLCELESPPPPYS--RY 214

  Fly   149 PLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSS 213
            |:|                    .|.|             .:....:.|::|..||
Human   215 PMD--------------------FLKP-------------TADCPDAVPSSAETGG--------- 237

  Fly   214 SSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRLTP 278
                                                |....||.:|:....::|.|.
Human   238 ------------------------------------TNYLAPGGLSDSQLLLEPGDR-------- 258

  Fly   279 PADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEV 343
                        :.||.::|:|..||||..:...:||:  |.|.|......||||.|::.|::::
Human   259 ------------SHWCVVAYWEEKTRVGRLYCVQEPSL--DIFYDLPQGNGFCLGQLNSDNKSQL 309

  Fly   344 VEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQS---PNCNQRYGWHPATVCKIPPGCNLKIF- 404
            |::.|..||.|::|......|:....|...||::|   .|.:.|    ...|.|:.||.::|.|
Human   310 VQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSR----TLLVHKVFPGFSIKAFD 370

  Fly   405 ----------NNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIEL 459
                      |:.||    .|....||          |:::|||||||..|.||.::|.|||:|:
Human   371 YEKAYSLQRPNDHEF----MQQPWTGF----------TVQISFVKGWGQCYTRQFISSCPCWLEV 421

  Fly   460 HLN 462
            ..|
Human   422 IFN 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_511079.1	MH1_R-SMAD	7..130	CDD:199812	37/110 (34%)
		MH2_SMAD_2_3	285..475	CDD:199826	61/192 (32%)
SMAD7	NP_005895.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	13..55
		MH1_SMAD_7	60..205	CDD:199818	40/117 (34%)
		Important for interaction with SMURF2	208..217		5/10 (50%)
		PY-motif	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	62/209 (30%)