Protein Alignment Smox and SMAD5

DIOPT Version :9

• Sequence 1: NP_001285006.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001001419.1
• Gene: SMAD5 / 4090
• HGNCID: 6771
• Length: 465
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 269/527 - (51%)
• Similarity: 325/527 - (61%)
• Gaps: 109/527 - (20%)

  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKI-KKNSQLEELERAISTQNCQTRCVT 64
            :..||...|||||..|:|:|    |.||:||||..||||: ||...:||||:|:|:....::|||
Human     7 LFSFTSPAVKRLLGWKQGDE----EEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVT 67

  Fly    65 VPRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIE 129
            :|||.........|||||||||||:||||||||.:||||||.||:.|..:::|:||||||||::|
Human    68 IPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVE 132

  Fly   130 LSILVPKSLP-----------------------------TPPDSIVDYPLDNHTHQIPNNTDYNA 165
            ..:|.|..:|                             |.|||.         || ||||.:
Human   133 SPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSF---------HQ-PNNTPF-- 185

  Fly   166 AIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSF 230
                                |:|.:|....:||::.      ..:|.:||...|.:|
Human   186 --------------------PLSPNSPYPPSPASST------YPNSPASSGPGSPFQ-------- 216

  Fly   231 GQNMDSQSSVLSVGSSIPNTGTPPPGYMSED-------GDPIDPNDNMNMSRLTP---PADAAPV 285
                            :| ..||||.||..|       ..|:|.::|| :.::.|   ..|..||
Human   217 ----------------LP-ADTPPPAYMPPDDQMGQDNSQPMDTSNNM-IPQIMPSISSRDVQPV 263

  Fly   286 MYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSE-RFCLGLLSNVNRNEVVEQTRR 349
            .|.||..||||.|||||.||||.||||..|:.|||||||||:: |||||||||||||..:|.|||
Human   264 AYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRR 328

  Fly   350 HIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLS 414
            ||||||.|||:||||:|||||||||||||.|||..:|:||.||||||..|:||||||||||.||:
Human   329 HIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLA 393

  Fly   415 QSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPR 479
            |||:.||||||:||:||||||||||||||||.||.|||||||||:||:|||||||:||||||||.
Human   394 QSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPL 458

  Fly   480 LPCSSMS 486
            .|.||:|
Human   459 NPISSVS 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	70/123 (57%)
		MH2_SMAD_2_3	285..475	CDD:199826	149/190 (78%)
SMAD5	NP_001001419.1	MH1_SMAD_1_5_9	10..133	CDD:199814	72/126 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..249		32/149 (21%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	156/199 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820