Protein Alignment Smox and SMAD2

DIOPT Version :9

• Sequence 1: NP_001285006.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001003652.1
• Gene: SMAD2 / 4087
• HGNCID: 6768
• Length: 467
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 307/539 - (56%)
• Similarity: 350/539 - (64%)
• Gaps: 128/539 - (23%)

  Fly     1 MLPFTPQVVKRLLALKK---------GNEDNSVEGKWSEKAVKNLVKKIKKNSQLEELERAISTQ 56
            :|||||.||||||..||         |.|.|..|.||.|||||:||||:||..:|:|||:||:||
Human     4 ILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQ 68

  Fly    57 NCQTRCVTVP------------------------------RSKPAPAGEHLRKGLPHVIYCRLWR 91
            ||.|:|||:|                              ||.........||||||||||||||
Human    69 NCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWR 133

  Fly    92 WPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDY-PLDNHTH 155
            ||||.|.:|||.:::|||||:|:|:|:|:|||||:::|..:|.|..:|...:.:.:. |||::||
Human   134 WPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTH 198

  Fly   156 QIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASA 220
            .||.||::.|.|       .||                                         |.
Human   199 SIPENTNFPAGI-------EPQ-----------------------------------------SN 215

  Fly   221 YQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNM-----SRLTPPA 280
            |                         ||.  ||||||:||||:..|...|.:|     :.|:|..
Human   216 Y-------------------------IPE--TPPPGYISEDGETSDQQLNQSMDTGSPAELSPTT 253

  Fly   281 --------DAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSN 337
                    |..||.|.||||||||:|||||.||||||||||||:|||||||||||||||||||||
Human   254 LSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSN 318

  Fly   338 VNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLK 402
            ||||..||.||||||:|||||||||||||||||||:|||||||||||||||||||||||||||||
Human   319 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLK 383

  Fly   403 IFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQW 467
            |||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||||||||||
Human   384 IFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQW 448

  Fly   468 LDRVLTQMGSPRLPCSSMS 486
            ||:||||||||.:.|||||
Human   449 LDKVLTQMGSPSVRCSSMS 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	78/161 (48%)
		MH2_SMAD_2_3	285..475	CDD:199826	176/189 (93%)
SMAD2	NP_001003652.1	MH1_SMAD_2_3	8..172	CDD:199815	80/163 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..251		22/118 (19%)
		PY-motif	221..225		3/3 (100%)
		MH2_SMAD_2_3	266..456	CDD:199826	176/189 (93%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1034
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1032
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48607
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104703
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.840