DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and SMAD1

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001003688.1	Gene:	SMAD1 / 4086	HGNCID:	6767	Length:	465	Species:	Homo sapiens

Alignment Length:	502	Identity:	264/502 - (52%)
Similarity:	321/502 - (63%)	Gaps:	58/502 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKI-KKNSQLEELERAISTQNCQTRCVT 64
            :..||...|||||..|:|:|    |.||:||||..||||: ||...:||||:|:|.....:.|||
Human     6 LFSFTSPAVKRLLGWKQGDE----EEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVT 66

  Fly    65 VPRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIE 129
            :|||.........|||||||||||:||||||||.:|||||:.||:.|..:::|:||||||||::|
Human    67 IPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVE 131

  Fly   130 LSILVPKSLPTPPDSIVDYPLDNHTHQIPNNTDYN-----AAIIRSASLSPPQYMELGGAGPVSV 189
            ..:|.|.                   .:|.:::||     .|..|:...:.| :|.|....|.|.
Human   132 SPVLPPV-------------------LVPRHSEYNPQHSLLAQFRNLGQNEP-HMPLNATFPDSF 176

  Fly   190 SSSASSTPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPP 254
             ...:|.|...:.....|:|..||||:...:.........|....|                |||
Human   177 -QQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPAD----------------TPP 224

  Fly   255 PGYMSEDGDPI--DPNDNMNMSRLTPP-------ADAAPVMYHEPAFWCSISYYELNTRVGETFH 310
            |.|:..: ||:  |.:..|:.:.:.||       .|...|.|.||..||||.|||||.||||.||
Human   225 PAYLPPE-DPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFH 288

  Fly   311 ASQPSITVDGFTDPSNSE-RFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSI 374
            ||..|:.|||||||||:: |||||||||||||..:|.|||||||||.|||:||||:|||||||||
Human   289 ASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSI 353

  Fly   375 FVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVK 439
            ||||.|||..:|:||.||||||.||:||||||||||.||:|||:.|||.||:||:||||||||||
Human   354 FVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVK 418

  Fly   440 GWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 486
            ||||||.||.|||||||||:||:|||||||:||||||||..|.||:|
Human   419 GWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	69/123 (56%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	149/190 (78%)
SMAD1	NP_001003688.1	MH1_SMAD_1_5_9	9..132	CDD:199814	71/126 (56%)
		PRK10263	<133..>244	CDD:236669	31/148 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..248		24/104 (23%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	156/199 (78%)
		L3 loop. /evidence=ECO:0000269\|PubMed:11779505	418..428		8/9 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820