DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and smad3b

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_778258.1	Gene:	smad3b / 326283	ZFINID:	ZDB-GENE-030128-4	Length:	423	Species:	Danio rerio

Alignment Length:	499	Identity:	303/499 - (60%)
Similarity:	345/499 - (69%)	Gaps:	91/499 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKIKKNSQLEELERAISTQNCQTRCVTV 65
            :|||||.:|||||..||| |.|..|.||.|||||:||||:||..||||||:||:|||..|:|:|:
Zfish     3 ILPFTPPIVKRLLGWKKG-EQNGQEEKWCEKAVKSLVKKLKKTGQLEELEKAITTQNINTKCITI 66

  Fly    66 PRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIEL 130
            |||.........:|||||||||||||||||||.:||:.::.||:|||.:|:|:|:|||||:::|.
Zfish    67 PRSLDGRLQVSHKKGLPHVIYCRLWRWPDLQSHHELRAVEMCEFAFHTKKDEVCVNPYHYQRVET 131

  Fly   131 SILVPKSLPTPPDSIVDY-PLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSAS 194
            .:|.|..:|...|...|: |||:::  ||.||      |..|.:.||
Zfish   132 PVLPPVLVPRRADIPTDFPPLDDYS--IPENT------IFPAGIEPP------------------ 170

  Fly   195 STPATAAGGGGGPSSSSSSSSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMS 259
                                    |.|                         ||.  ||||||:|
Zfish   171 ------------------------SNY-------------------------IPE--TPPPGYLS 184

  Fly   260 EDGDPIDPNDNMNMSRLTP--------PA----DAAPVMYHEPAFWCSISYYELNTRVGETFHAS 312
            |||:..|...:.:|...:|        ||    |..||.|.|.||||||||||||.|||||||||
Zfish   185 EDGETSDHQMSHSMDTGSPTLSPNPVSPANSNLDLQPVTYCESAFWCSISYYELNQRVGETFHAS 249

  Fly   313 QPSITVDGFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQ 377
            |||:||||||||||:||||||||||||||..||.||||||:|||||||||||||||||||:||||
Zfish   250 QPSLTVDGFTDPSNAERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQ 314

  Fly   378 SPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWG 442
            ||||||||||||||||||||||||||||||||||||:|||:||||||||||||||||||||||||
Zfish   315 SPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWG 379

  Fly   443 AEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSSMS 486
            |||||||||||||||||||||||||||:||||||||.|.|||:|
Zfish   380 AEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPNLRCSSVS 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	75/122 (61%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	175/189 (93%)
smad3b	NP_778258.1	MH1_SMAD_2_3	7..131	CDD:199815	77/124 (62%)
smad3b	NP_778258.1	MH2_SMAD_2_3	222..412	CDD:199826	175/189 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	349	1.000	Domainoid score	I990
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55937
Inparanoid	1	1.050	579	1.000	Inparanoid score	I996
OMA	1	1.010	-	-		QHG48607
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm24510
orthoMCL	1	0.900	-	-		OOG6_104703
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5017
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870