DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and smad1

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_571431.2	Gene:	smad1 / 30628	ZFINID:	ZDB-GENE-991119-8	Length:	472	Species:	Danio rerio

Alignment Length:	523	Identity:	264/523 - (50%)
Similarity:	322/523 - (61%)	Gaps:	93/523 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPFTPQVVKRLLALKKGNEDNSVEGKWSEKAVKNLVKKI-KKNSQLEELERAISTQNCQTRCVT 64
            :..||...|||||..|:|:|    |.||:||||..||||: ||...:||||||:|.....:.|||
Zfish     6 LFSFTSPAVKRLLGWKQGDE----EEKWAEKAVDALVKKLKKKKGAMEELERALSCPGQPSNCVT 66

  Fly    65 VPRSKPAPAGEHLRKGLPHVIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIE 129
            :|||.........|||||||||||:||||||||.:|||.|:.||:.|..:::::||||||||:::
Zfish    67 IPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALECCEFPFGSKQKDVCINPYHYKRVD 131

  Fly   130 LSILVPKSLPTPPDSIVDYPLDNHTHQIPNNTDYNAAIIRSASLSP-------------PQY--- 178
            ..:|.|.                   .:|.|:::||.:    |:.|             ||.
Zfish   132 SPVLPPV-------------------LVPRNSEFNAKL----SMLPRFRNPLHQTEPPMPQNATF 173

  Fly   179 -----MELGGAGPVSVSSSASSTPATAAGGGGGPSS--SSSSSSSAASAYQQQQQQLSFGQNMDS 236
                 .:...|.|.:.:|..:|.|::...|.|..::  .|.|||...|.:|..:
Zfish   174 PDSFPQQPANALPFTPNSPTNSYPSSPNSGTGSTATFPHSPSSSDPGSPFQMPE----------- 227

  Fly   237 QSSVLSVGSSIPNTGTPPPGYMSED-------GDPID-----PNDNMNMSRLTPPADAAPVMYHE 289
                           ||||.||..:       ..|:|     ||..:.:|..|   |..||.|.|
Zfish   228 ---------------TPPPAYMPPEEPMTQDCPQPMDTNLLAPNLPLEISNRT---DVHPVAYQE 274

  Fly   290 PAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNS-ERFCLGLLSNVNRNEVVEQTRRHIGK 353
            |..||||.|||||.||||.|.||..|:.|||||||||: .|||||||||||||..:|.|||||||
Zfish   275 PKHWCSIVYYELNNRVGEAFLASSTSVLVDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGK 339

  Fly   354 GVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVS 418
            ||.|||:||||:|||||||||||||.|||..:|:||.||||||..|:||||||||||.||:|||:
Zfish   340 GVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSRCSLKIFNNQEFAELLAQSVN 404

  Fly   419 QGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCS 483
            .||||||:||:||||||||||||||||.||.|||||||||:||:|||||||:||||||||..|.|
Zfish   405 HGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPIS 469

  Fly   484 SMS 486
            |:|
Zfish   470 SVS 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	68/123 (55%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	148/190 (78%)
smad1	NP_571431.2	MH1_SMAD_1_5_9	9..132	CDD:199814	70/126 (56%)
		DUF4045	<110..275	CDD:330572	49/216 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..238		21/105 (20%)
		MH2_SMAD_1_5_9	272..472	CDD:199822	155/199 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920