DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and Smad2

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001264379.1	Gene:	Smad2 / 29357	RGDID:	3031	Length:	467	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	307/539 - (56%)
Similarity:	349/539 - (64%)	Gaps:	128/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPFTPQVVKRLLALKK---------GNEDNSVEGKWSEKAVKNLVKKIKKNSQLEELERAISTQ 56
            :|||||.||||||..||         |.|.|..|.||.|||||:||||:||..:|:|||:||:||
  Rat     4 ILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQ 68

  Fly    57 NCQTRCVTVP------------------------------RSKPAPAGEHLRKGLPHVIYCRLWR 91
            ||.|:|||:|                              ||.........||||||||||||||
  Rat    69 NCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWR 133

  Fly    92 WPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDY-PLDNHTH 155
            ||||.|.:|||.:::|||||.|:|:|:|:|||||:::|..:|.|..:|...:.:.:. |||::||
  Rat   134 WPDLHSHHELKAIENCEYAFSLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTH 198

  Fly   156 QIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSSSSAASA 220
            .||.||::.|.|       .||                                         |.
  Rat   199 SIPENTNFPAGI-------EPQ-----------------------------------------SN 215

  Fly   221 YQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNM-----SRLTPPA 280
            |                         ||.  ||||||:||||:..|...|.:|     :.|:|..
  Rat   216 Y-------------------------IPE--TPPPGYISEDGETSDQQLNQSMDTGSPAELSPTT 253

  Fly   281 --------DAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSN 337
                    |..||.|.||||||||:|||||.||||||||||||:|||||||||||||||||||||
  Rat   254 LSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSN 318

  Fly   338 VNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLK 402
            ||||..||.||||||:|||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   319 VNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLK 383

  Fly   403 IFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQW 467
            |||||||||||:|||:|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   384 IFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQW 448

  Fly   468 LDRVLTQMGSPRLPCSSMS 486
            ||:||||||||.:.|||||
  Rat   449 LDKVLTQMGSPSVRCSSMS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	78/161 (48%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	176/189 (93%)
Smad2	NP_001264379.1	MH1	8..172	CDD:412134	80/163 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..251		22/118 (19%)
		PY-motif. /evidence=ECO:0000250	221..225		3/3 (100%)
		MH2_SMAD_2_3	266..456	CDD:199826	176/189 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1001
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I999
OMA	1	1.010	-	-		QHG48607
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104703
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840