DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smox and daf-8

DIOPT Version :9

Sequence 1:	NP_001285006.1	Gene:	Smox / 31738	FlyBaseID:	FBgn0025800	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_492321.1	Gene:	daf-8 / 187612	WormBaseID:	WBGene00000904	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	171/564 - (30%)
Similarity:	243/564 - (43%)	Gaps:	110/564 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PFTPQVVKRLLALKKGNEDNSVEGK----WSEKAVKNLVKKIKKNSQLEELERAISTQNCQTRCV 63
            |..|::  ..:|.|...|....||.    |:.|..:.|.:..||:...|....|:...:.:|||
Worm     9 PTDPRL--EAMAQKVLEETIITEGDGTIYWALKVTRLLSRVAKKHQCFEAFYDAVIKGDPKTRC- 70

  Fly    64 TVPRSKPAPA-GEHLRKGLPHVIYC--RLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHY 125
                   .|| .|.|.......|.|  |.:|:|.::.::::|.:..|.:||:.....:|:|||||
Worm    71 -------CPAHNEKLIGNFGRAIMCVLRAFRFPVIRYESQVKSILTCRHAFNSHSRNVCLNPYHY 128

  Fly   126 KKIEL------SILVPKSLP--TPP----DSIVDY-PLDNHTHQIPNNTDYNAAIIR-------- 169
            :.:||      .|:|.|.|.  .||    |::.|: ..|....|:..:.|.....:|
Worm   129 RWVELPTCQVPPIIVNKELDYGEPPIRTEDALDDWNQKDLKEEQVVASWDVPNVTMRGDEIKLLY 193

  Fly   170 ---SASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSSS--SSAASAYQQQQQQ-- 227
               :|.....|||..|..|...                |.|.||::.|  ||.||..||..:|
Worm   194 DRYAAENGDFQYMNYGNFGSFD----------------GSPCSSTTMSLGSSFASLLQQSNRQDD 242

  Fly   228 ------------------------------LSFGQNMDSQSSVLSV----GSSIPNTGTPPPGYM 258
                                          :|..|.|...|.|..:    ..|..|.|...|.|
Worm   243 EEPGYYRSGLSSPASHAASPREFIPNGNDTISLDQEMMDDSEVSDIMHSENFSSENNGNRKPTY- 306

  Fly   259 SEDGDPIDP--------NDNMNMSRLTPPADAAP-VMYHEPAFWCSISYYELNTRVGETFHASQP 314
             .||.||.|        :..:.:..|:..|.... |.|.|...|..:.|||..|.:||.......
Worm   307 -ADGRPITPIEPRPLYRSSALELGDLSRQAGIYECVEYEESPSWLKLIYYEEGTMIGEKADVEGH 370

  Fly   315 SITVDGF----TDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRLYYIGGEVFAECLSDSSIF 375
            ...:|||    ||.....||.||..:|.||:....:.|..||||||.|.:.|||:.|.|.:..:|
Worm   371 HCLIDGFTASRTDSETRSRFSLGWYNNPNRSPQTAEVRGLIGKGVRFYLLAGEVYVENLCNIPVF 435

  Fly   376 VQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKG 440
            |||...|.:.|:...||.|:||...:|:|:.:.|:..|..:..:.::.||.|:||||:|:||.||
Worm   436 VQSIGANMKNGFQLNTVSKLPPTGTMKVFDMRLFSKQLRTAAEKTYQDVYCLSRMCTVRVSFCKG 500

  Fly   441 WGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLPCSS 484
            ||..|||.||..:|.|.:.|||.|:.|:|.|||.||:|...|||
Worm   501 WGEHYRRSTVLRSPVWFQAHLNNPMHWVDSVLTCMGAPPRICSS 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_001285006.1	MH1_R-SMAD	7..130	CDD:199812	34/129 (26%)
Smox	NP_001285006.1	MH2_SMAD_2_3	285..475	CDD:199826	80/193 (41%)
daf-8	NP_492321.1	DWA	32..135	CDD:214708	31/110 (28%)
daf-8	NP_492321.1	DWB	348..522	CDD:197770	69/173 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840