Protein Alignment Smox and daf-3

DIOPT Version :10

• Sequence 1: NP_511079.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001300341.1
• Gene: daf-3 / 180431
• WormBaseID: WBGene00000899
• Length: 895
• Species: Caenorhabditis elegans
• Alignment Length: 643
• Identity: 146/643 - (22%)
• Similarity: 238/643 - (37%)
• Gaps: 200/643 - (31%)

  Fly    22 NSVEGKWSEKAVKNLVKKIK-KNSQLEEL-ERAISTQNCQTRCVTVPRSKPAPAGEHLRKGLPHV 84
            |:::.::.:||.::||||:| |.:.|:.| :..:|.....|.|:|:||:.......|.|||.|||
 Worm   234 NNIDREFDQKACESLVKKLKDKKNDLQNLIDVVLSKGTKYTGCITIPRTLDGRLQVHGRKGFPHV 298

  Fly    85 IYCRLWRWPDLQSQNELKPLDHCEYAFHLRKE---EICINPYHYKKIELSILV------PKSLP- 139
            :|.:|||:.:: ::||.:.:|||::||.::.:   |:|:|||||:.:..:::|      .:.:|
 Worm   299 VYGKLWRFNEM-TKNETRHVDHCKHAFEMKSDMVGEVCVNPYHYEIVIGTMIVGQRDHDNRDMPP 362

  Fly   140 --------------------TPPDSIVDYPLDNHT-----------------HQIPNNTDYNAAI 167
                                .||.||...|::.||                 |.:|:...:|..:
 Worm   363 PHQRYHTPGRQDPVDDMSRFIPPASIRPPPMNMHTRPQPMPQQLPSVGATFAHPLPHQAPHNPGV 427

  Fly   168 IRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGG--GPSSSSSSSS-----------SAAS 219
            ....|::|..:..| ...|:.........|.....|.|  |||.||.:::           |..:
 Worm   428 SHPYSIAPQTHYPL-NMNPIPQMPQMPQMPPPLHQGYGMNGPSCSSENNNPFHQNHHYNDISHPN 491

  Fly   220 AY-----------------------QQQQQQLSFGQNMDSQSSVLSVG--SSIPNTGTPP----- 254
            .|                       ||..|.....||..||......|  ..:||  .||
 Worm   492 HYSYDCGPNLYGFPTPYPDFHHPFNQQPHQPPQLSQNHTSQQGSHQPGHQGQVPN--DPPISRPV 554

  Fly   255 --PGYM---------------------SEDGDPIDPNDNMNMSRLTPPADAAPVM---------- 286
              |..:                     ||....|..:.|..:.....|.....|:
 Worm   555 LQPSTVTLDVFRRYCRQTFGNRFFEGESEQSGAIIRSSNKFIEEFDSPICGVTVVRPRMTDGEVL 619

  Fly   287 ---------YHE-------------------PAF------WCSISYYELNTRVGETFHASQPSIT 317
                     ||:                   |..      |.:|.|||.|.::||. ..|:.:..
 Worm   620 ENIMPEDAPYHDICKFILRLTSESVTFSGEGPEVSDLNEKWGTIVYYEKNLQIGEK-KCSRGNFH 683

  Fly   318 VD-GFTDPSNSERFCLGLLSNVNRNEVVEQTRRHIGKGVRL-YYIGGEVFAECLSDSSIFVQSPN 380
            || ||....|  |:.|||..|..|..|..:.|:.|..|:|. |...|.|:.:......:||.|..
 Worm   684 VDGGFICSEN--RYSLGLEPNPIREPVAFKVRKAIVDGIRFSYKKDGSVWLQNRMKYPVFVTSGY 746

  Fly   381 CNQRYGWHPATVCKIPPGC-NLKIFN-------------NQEFAALLSQSVSQGFEAVYQ----- 426
            .:::.|...........|| ::|.|.             :::.|.:..|........:|:
 Worm   747 LDEQSGGLKKDKVHKVYGCASIKTFGFNVSKQIIRDALLSKQMATMYLQGKLTPMNYIYEKKTQE 811

  Fly   427 ------------LTRMCTIRMSFVKGWGAEY-RRQTVTSTPCWIELHLNGPLQWLDRV 471
                        |.:.|.:|:||.||:|..| .|.::...|.||||.:|....::|.:
 Worm   812 ELRREATRTTDSLAKYCCVRVSFCKGFGEAYPERPSIHDCPVWIELKINIAYDFMDSI 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_511079.1	MH1_R-SMAD	7..130	CDD:199812	42/112 (38%)
		MH2_SMAD_2_3	285..475	CDD:199826	60/265 (23%)
daf-3	NP_001300341.1	MH1_SMAD_4	218..346	CDD:199816	42/112 (38%)
		Atrophin-1	<355..>560	CDD:460830	38/207 (18%)
		DWB	659..860	CDD:197770	54/203 (27%)