Protein Alignment Smox and Smad7

DIOPT Version :10

• Sequence 1: NP_511079.1
• Gene: Smox / 31738
• FlyBaseID: FBgn0025800
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001036125.1
• Gene: Smad7 / 17131
• MGIID: 1100518
• Length: 426
• Species: Mus musculus
• Alignment Length: 458
• Identity: 120/458 - (26%)
• Similarity: 183/458 - (39%)
• Gaps: 152/458 - (33%)

  Fly    31 KAVKNLVKKIKKNSQLEELERAISTQ-NCQTRCVTVP-----RSKP-APAGEHLRK-----GLPH 83
            ||:.:.|.|..|..|||.|.:|:.:: ..:|.|:.:|     |..| |||.....:     .||
Mouse    93 KALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLP- 156

  Fly    84 VIYCRLWRWPDLQSQNELKPLDHCEYAFHLRKEEICINPYHYKKIELSILVPKSLPTPPDSIVDY 148
            ::.|:::|||||:..:|:|.|..||....:..|.:|.||:|     ||.|.....|.||.|  .|
Mouse   157 LLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHH-----LSRLCELESPPPPYS--RY 214

  Fly   149 PLDNHTHQIPNNTDYNAAIIRSASLSPPQYMELGGAGPVSVSSSASSTPATAAGGGGGPSSSSSS 213
            |:|                          :::.....|.:|.|||.:         ||
Mouse   215 PMD--------------------------FLKPTAGCPDAVPSSAET---------GG------- 237

  Fly   214 SSSAASAYQQQQQQLSFGQNMDSQSSVLSVGSSIPNTGTPPPGYMSEDGDPIDPNDNMNMSRLTP 278
                                                |....||.:|:....::|.|.
Mouse   238 ------------------------------------TNYLAPGGLSDSQLLLEPGDR-------- 258

  Fly   279 PADAAPVMYHEPAFWCSISYYELNTRVGETFHASQPSITVDGFTDPSNSERFCLGLLSNVNRNEV 343
                        :.||.::|:|..||||..:...:||:  |.|.|......||||.|::.|::::
Mouse   259 ------------SHWCVVAYWEEKTRVGRLYCVQEPSL--DIFYDLPQGNGFCLGQLNSDNKSQL 309

  Fly   344 VEQTRRHIGKGVRLYYIGGEVFAECLSDSSIFVQS---PNCNQRYGWHPATVCKIPPGCNLKIF- 404
            |::.|..||.|::|......|:....|...||::|   .|.:.|    ...|.|:.||.::|.|
Mouse   310 VQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSR----TLLVHKVFPGFSIKAFD 370

  Fly   405 ----------NNQEFAALLSQSVSQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIEL 459
                      |:.||    .|....||          |:::|||||||..|.||.::|.|||:|:
Mouse   371 YEKAYSLQRPNDHEF----MQQPWTGF----------TVQISFVKGWGQCYTRQFISSCPCWLEV 421

  Fly   460 HLN 462
            ..|
Mouse   422 IFN 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smox	NP_511079.1	MH1_R-SMAD	7..130	CDD:199812	36/110 (33%)
		MH2_SMAD_2_3	285..475	CDD:199826	61/192 (32%)
Smad7	NP_001036125.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..42
		MH1_SMAD_7	60..205	CDD:199818	39/117 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..87
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		5/10 (50%)
		PY-motif. /evidence=ECO:0000250	208..211		1/2 (50%)
		MH2_SMAD_7	254..424	CDD:199825	62/209 (30%)