DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2120 and ZNF486

DIOPT Version :9

Sequence 1:NP_572446.2 Gene:CG2120 / 31737 FlyBaseID:FBgn0030005 Length:315 Species:Drosophila melanogaster
Sequence 2:NP_443084.2 Gene:ZNF486 / 90649 HGNCID:20807 Length:463 Species:Homo sapiens


Alignment Length:259 Identity:82/259 - (31%)
Similarity:122/259 - (47%) Gaps:35/259 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 NGALQQRNTTEHKPTDMCKPKR------TPTTKRHRTTG-KDHTCDICDRRFSEAYNLRIHKMTH 121
            |....:|..||.||....:..:      |.||.:...|| |.:.|:.|.:.|:.:.:|..||:||
Human   168 NSKRHKRRHTEKKPLKYIEGDKAFNQSSTHTTHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITH 232

  Fly   122 TDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCL 186
            |.|||:.|.||||.|:..:....|...|:.|:|:.|:.|||.|.|...||.|:.:||||:||.| 
Human   233 TREKPYKCEECGKVFKYFSSFTTHKKIHSGEKPYICEECGKAFMYPYTLTTHKIIHTGEQPYKC- 296

  Fly   187 ATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHP--LAEQEQRDTSALSFTCPVCSRVLTDQCYLS 249
             .:|..:|:                      ||  |:..::..|....:||..|.:.......||
Human   297 -KECDKAFN----------------------HPATLSSHKKIHTGEKPYTCDKCGKAFISSSILS 338

  Fly   250 IHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            .|.|.|..::.:.|  .||||.|..:|.|..|:|.||.::|:.|..|...|...:...:|.:.|
Human   339 KHEKIHTGEKPYKC--EECGKAFTRSSHLTMHKIIHTGEKPYKCEECGKAFTWSAGLHKHRRTH 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2120NP_572446.2 C2H2 Zn finger 101..121 CDD:275368 6/19 (32%)
zf-H2C2_2 113..138 CDD:290200 15/24 (63%)
C2H2 Zn finger 129..149 CDD:275368 7/19 (37%)
zf-H2C2_2 142..166 CDD:290200 9/23 (39%)
COG5048 151..>264 CDD:227381 32/114 (28%)
C2H2 Zn finger 157..177 CDD:275368 9/19 (47%)
C2H2 Zn finger 185..206 CDD:275368 3/20 (15%)
C2H2 Zn finger 235..255 CDD:275368 6/19 (32%)
C2H2 Zn finger 263..285 CDD:275368 10/21 (48%)
C2H2 Zn finger 293..313 CDD:275368 4/19 (21%)
ZNF486NP_443084.2 KRAB 13..71 CDD:214630
KRAB 15..52 CDD:279668
C2H2 Zn finger 155..176 CDD:275368 2/7 (29%)
COG5048 188..>463 CDD:227381 76/239 (32%)
C2H2 Zn finger 188..204 CDD:275368 3/15 (20%)
C2H2 Zn finger 212..232 CDD:275368 6/19 (32%)
zf-H2C2_2 224..249 CDD:290200 15/24 (63%)
C2H2 Zn finger 240..260 CDD:275368 7/19 (37%)
C2H2 Zn finger 268..288 CDD:275368 9/19 (47%)
zf-H2C2_2 281..305 CDD:290200 12/47 (26%)
C2H2 Zn finger 296..316 CDD:275368 6/43 (14%)
zf-H2C2_2 309..333 CDD:290200 5/23 (22%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
zf-H2C2_2 337..361 CDD:290200 11/25 (44%)
C2H2 Zn finger 352..372 CDD:275368 10/21 (48%)
zf-H2C2_2 364..388 CDD:290200 8/23 (35%)
C2H2 Zn finger 380..400 CDD:275368 4/19 (21%)
zf-H2C2_2 395..417 CDD:290200 2/6 (33%)
C2H2 Zn finger 408..428 CDD:275368
zf-H2C2_2 420..444 CDD:290200
C2H2 Zn finger 436..456 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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