DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF700

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001258777.1	Gene:	ZNF700 / 90592	HGNCID:	25292	Length:	745	Species:	Homo sapiens

Alignment Length:	319	Identity:	101/319 - (31%)
Similarity:	149/319 - (46%)	Gaps:	43/319 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDL-------SGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCK- 82
            |.|..:.||....|       ||:: |.|.:....|..|    |::.....|..:..:|. .||
Human   311 CKECGKAFAYTSSLRRHERTHSGKK-PYECKQYGEGLSY----LISFQTHIRMNSGERPY-KCKI 369

  Fly    83 -PKRTPTTKRHRTTGKDHT------CDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLN 140
             .|...:.|..:|..|.||      |..|.:.|:.:.:.|.|:..||.|||:.|.:|||.||..:
Human   370 CGKGFYSAKSFQTHEKTHTGEKRYKCKQCGKAFNLSSSFRYHERIHTGEKPYECKQCGKAFRSAS 434

  Fly   141 KLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTK 205
            :||:|..|||.|:|::|..|||.||..::|.||.|.|||||||.|  .:|..:|..:...:||.:
Human   435 QLRVHGGTHTGEKPYECKECGKAFRSTSHLRVHGRTHTGEKPYEC--KECGKAFRYVKHLQIHER 497

  Fly   206 L-RHAAQTDPDPEHP----LAEQ-----------EQRDTSALSFTCPVCSRVLTDQCYLSIHLKR 254
            . :|...  |..|.|    :.|:           |:..|....:.|..|.:.......|..|.:.
Human   498 TEKHIRM--PSGERPYKCSICEKGFYSAKSFQTHEKTHTGEKPYECNQCGKAFRCCNSLRYHERT 560

  Fly   255 HYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |..::.:.|.|  |||.|.|||.|:.|:..||.::|:.|..|...|...||.::|.:.|
Human   561 HTGEKPYECKQ--CGKAFRSASHLRMHERTHTGEKPYECKQCGKAFSCASNLRKHGRTH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	5/19 (26%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	36/128 (28%)
		C2H2 Zn finger	157..177	CDD:275368	10/19 (53%)
		C2H2 Zn finger	185..206	CDD:275368	5/20 (25%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	11/21 (52%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF700	NP_001258777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		KRAB	27..>69	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368
		COG5048	224..636	CDD:227381	101/319 (32%)
		C2H2 Zn finger	227..247	CDD:275368
		zf-H2C2_2	243..264	CDD:290200
		C2H2 Zn finger	255..275	CDD:275368
		zf-H2C2_2	268..292	CDD:290200
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	298..320	CDD:290200	3/8 (38%)
		C2H2 Zn finger	311..331	CDD:275368	5/19 (26%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		zf-H2C2_2	379..403	CDD:290200	6/23 (26%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		zf-H2C2_2	463..488	CDD:290200	14/26 (54%)
		C2H2 Zn finger	479..498	CDD:275368	5/20 (25%)
		C2H2 Zn finger	513..533	CDD:275368	2/19 (11%)
		zf-H2C2_2	525..550	CDD:290200	4/24 (17%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
		zf-H2C2_2	553..578	CDD:290200	9/26 (35%)
		C2H2 Zn finger	569..589	CDD:275368	11/21 (52%)
		zf-H2C2_2	581..606	CDD:290200	8/24 (33%)
		C2H2 Zn finger	597..617	CDD:275368	6/19 (32%)
		zf-H2C2_2	609..634	CDD:290200	3/9 (33%)
		C2H2 Zn finger	625..645	CDD:275368
		zf-H2C2_2	637..660	CDD:290200
		C2H2 Zn finger	653..673	CDD:275368
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000