DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF160

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	363	Identity:	104/363 - (28%)
Similarity:	146/363 - (40%)	Gaps:	99/363 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LADDDLG-NYDVCLEDLQLFAQLEDLSGERLPMEMELL----NPGSEYDLLELVNGALQQRNT-- 72
            |.::.|| ::...|.:||||      .||....|...:    |.||....|:.:..::|...:
Human   176 LMNNQLGVSFHSHLPELQLF------QGEGKMYECNQVEKSTNNGSSVSPLQQIPSSVQTHRSKK 234

  Fly    73 ----------TEHKPTDMCKPKRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPH 127
                      |:.:..:.|              ||.:.|:.|.:.|::..||..|:..|:.|||:
Human   235 YHELNHFSLLTQRRKANSC--------------GKPYKCNECGKAFTQNSNLTSHRRIHSGEKPY 285

  Fly   128 VCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHL 192
            .|.||||.|...:.|.||.|.||.|:|:||..|||.||:.:||..|||:|||||||.|  .:|..
Human   286 KCSECGKTFTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKC--NECGK 348

  Fly   193 SF--------------------------------HSIHARRIHTKLRHAAQTDPDPEHP------ 219
            :|                                |.|...||||           .|.|
Human   349 AFRGHSNLTTHQLIHTGEKPFKCNECGKLFTQNSHLISHWRIHT-----------GEKPYKCNEC 402

  Fly   220 ---------LAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSA 275
                     ||..:...|....:.|..|.:|.....||..|.:.|..::.:.|  .||||.|...
Human   403 GKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYLGRHRRVHTGEKPYKC--NECGKAFSMH 465

  Fly   276 SELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |.|..||:.||..:||.|..|...|.:.|....|.::|
Human   466 SNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	14/23 (61%)
		COG5048	151..>264	CDD:227381	42/159 (26%)
		C2H2 Zn finger	157..177	CDD:275368	11/19 (58%)
		C2H2 Zn finger	185..206	CDD:275368	9/52 (17%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	6/21 (29%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	271..295	CDD:290200	12/23 (52%)
		C2H2 Zn finger	287..307	CDD:275368	10/19 (53%)
		zf-H2C2_2	299..324	CDD:290200	14/24 (58%)
		C2H2 Zn finger	315..335	CDD:275368	11/19 (58%)
		zf-H2C2_2	327..350	CDD:290200	14/24 (58%)
		C2H2 Zn finger	343..363	CDD:275368	3/21 (14%)
		zf-H2C2_2	355..380	CDD:290200	0/24 (0%)
		COG5048	367..810	CDD:227381	38/150 (25%)
		C2H2 Zn finger	371..391	CDD:275368	3/19 (16%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		zf-H2C2_2	411..436	CDD:290200	6/24 (25%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	9/25 (36%)
		C2H2 Zn finger	455..475	CDD:275368	10/21 (48%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		zf-H2C2_2	496..519	CDD:290200	2/8 (25%)
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		zf-H2C2_2	607..632	CDD:290200
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..659	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000