DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF30

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001092907.1	Gene:	ZNF30 / 90075	HGNCID:	13090	Length:	624	Species:	Homo sapiens

Alignment Length:	338	Identity:	97/338 - (28%)
Similarity:	140/338 - (41%)	Gaps:	71/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LADDDLGNYDV-CLEDLQLFAQLEDLSGERLPMEMELLNPGSEY--DLLELVNGALQQRNTTEHK 76
            |.||.:|..:: ..|:...||..:.:|.:: |.|.:      ||  .|.:.......:|..:..|
Human    90 LEDDTIGCKEMPTSENCPSFALHQKISRQK-PRECQ------EYGKTLCQDSKPVQHERIHSSEK 147

  Fly    77 PTDMCKPKRTPTTKRHRTT------------------------------GKDHT------CDICD 105
            | :.||......:..|:.|                              |:.||      |..|.
Human   148 P-NRCKECGKNFSNGHQLTIHQRLHVGEKPYKYEKCGKAFISGSAFVKHGRIHTGEKPLKCKQCG 211

  Fly   106 RRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYL 170
            :..|.:|.|.:||..||.:||:.|.||||.|....||..|..|||.|:|..|:.|||.|...:||
Human   212 KTISGSYQLTVHKSIHTGKKPYECGECGKAFLVYGKLTRHQSTHTGEKPFGCEECGKAFSTFSYL 276

  Fly   171 TVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFTC 235
            ..|:|:||.||||.|  .:|..:|.:                    ..|||:.::..|....:.|
Human   277 VQHQRIHTSEKPYEC--KECGKAFST--------------------SSPLAKHQRIHTGEKPYEC 319

  Fly   236 PVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARF 300
            ..|.:..|....|:.|...|..::.|.|  .||||.|..:|.|..||..|.:.:|:.|..|...|
Human   320 KECGKSFTVYGQLTRHQSIHTGEKPFEC--KECGKAFRLSSFLHAHQRIHAEIKPYGCKECGRTF 382

  Fly   301 LRKSNHKQHLKVH 313
            .|.|...||.::|
Human   383 SRASYLVQHGRLH 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	12/23 (52%)
		COG5048	151..>264	CDD:227381	31/112 (28%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	3/20 (15%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
ZNF30	NP_001092907.1	KRAB	14..75	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	<97..302	CDD:227381	62/234 (26%)
		C2H2 Zn finger	123..143	CDD:275368	4/25 (16%)
		C2H2 Zn finger	151..171	CDD:275368	4/19 (21%)
		C2H2 Zn finger	179..199	CDD:275368	1/19 (5%)
		C2H2 Zn finger	207..227	CDD:275368	7/19 (37%)
		C2H2 Zn finger	235..255	CDD:275368	9/19 (47%)
		COG5048	245..624	CDD:227381	57/175 (33%)
		C2H2 Zn finger	263..283	CDD:275368	9/19 (47%)
		zf-H2C2_2	275..300	CDD:290200	13/26 (50%)
		C2H2 Zn finger	291..311	CDD:275368	6/41 (15%)
		zf-H2C2_2	304..327	CDD:290200	5/22 (23%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	332..354	CDD:290200	9/23 (39%)
		C2H2 Zn finger	347..367	CDD:275368	10/21 (48%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368
		zf-H2C2_2	415..438	CDD:290200
		C2H2 Zn finger	431..451	CDD:275368
		zf-H2C2_2	444..466	CDD:290200
		C2H2 Zn finger	459..479	CDD:275368
		zf-H2C2_2	471..496	CDD:290200
		C2H2 Zn finger	487..507	CDD:275368
		zf-H2C2_2	499..524	CDD:290200
		C2H2 Zn finger	515..535	CDD:275368
		zf-H2C2_2	527..551	CDD:290200
		C2H2 Zn finger	543..563	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		zf-H2C2_2	584..608	CDD:290200
		C2H2 Zn finger	599..619	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000