DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF594

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_115919.1	Gene:	ZNF594 / 84622	HGNCID:	29392	Length:	807	Species:	Homo sapiens

Alignment Length:	323	Identity:	90/323 - (27%)
Similarity:	139/323 - (43%)	Gaps:	58/323 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VCLEDLQLFAQLEDLSGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCKPKRTPTT 89
            :|.|..:.|.|..:|...:     ::.:.|:.|:..|.........|...|
Human   184 ICHECGKDFNQSSNLVRHK-----QIHSGGNPYECKECGKAFKGSSNLVLH-------------- 229

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            :|..:.||.:.|:.|.:.||::.:|.||...||.|||:.|.:||:.|.|.:.|..|...||.|:|
Human   230 QRIHSRGKPYLCNKCGKAFSQSTDLIIHHRIHTGEKPYECYDCGQMFSQSSHLVPHQRIHTGEKP 294

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHP 219
            .||:.|.|.||..::||.|:|||:|||||.|  ..|..:|....|...|.:| ||.:...:.|..
Human   295 LKCNECEKAFRQHSHLTEHQRLHSGEKPYEC--HRCGKTFSGRTAFLKHQRL-HAGEKIEECEKT 356

  Fly   220 LAE-----QEQR-----------------------------DTSALSFTCPVCSRVLTDQCYLSI 250
            .::     :|||                             .|....:.|..|.:.......|..
Human   357 FSKDEELREEQRIHQEEKAYWCNQCGRNFQGTSDLIRHQVTHTGEKPYECKECGKTFNQSSDLLR 421

  Fly   251 HLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |.:.|..::  ||...:|||.|..:|:|..|...||.::|:.|..|...|.::|:...|.|:|
Human   422 HHRIHSGEK--PCVCSKCGKSFRGSSDLIRHHRVHTGEKPYECSECGKAFSQRSHLVTHQKIH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	7/19 (37%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	38/146 (26%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	5/20 (25%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF594	NP_115919.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		COG5048	96..518	CDD:227381	90/323 (28%)
		C2H2 Zn finger	105..121	CDD:275368
		C2H2 Zn finger	129..149	CDD:275368
		C2H2 Zn finger	157..177	CDD:275368
		C2H2 Zn finger	185..205	CDD:275368	5/24 (21%)
		C2H2 Zn finger	213..233	CDD:275368	4/33 (12%)
		C2H2 Zn finger	241..261	CDD:275368	7/19 (37%)
		C2H2 Zn finger	269..289	CDD:275368	7/19 (37%)
		C2H2 Zn finger	297..317	CDD:275368	9/19 (47%)
		C2H2 Zn finger	325..345	CDD:275368	6/22 (27%)
		C2H2 Zn finger	351..370	CDD:275370	4/18 (22%)
		COG5048	378..779	CDD:227381	25/107 (23%)
		C2H2 Zn finger	378..398	CDD:275368	0/19 (0%)
		zf-H2C2_2	390..415	CDD:290200	3/24 (13%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		zf-H2C2_2	446..471	CDD:290200	8/24 (33%)
		C2H2 Zn finger	462..482	CDD:275368	6/19 (32%)
		zf-H2C2_2	474..499	CDD:290200	3/9 (33%)
		C2H2 Zn finger	490..510	CDD:275368
		C2H2 Zn finger	518..538	CDD:275368
		C2H2 Zn finger	570..590	CDD:275368
		zf-H2C2_2	582..607	CDD:290200
		C2H2 Zn finger	598..618	CDD:275368
		zf-H2C2_2	610..633	CDD:290200
		C2H2 Zn finger	626..646	CDD:275368
		zf-H2C2_2	638..663	CDD:290200
		C2H2 Zn finger	654..674	CDD:275368
		zf-H2C2_2	666..691	CDD:290200
		C2H2 Zn finger	682..702	CDD:275368
		C2H2 Zn finger	710..730	CDD:275368
		C2H2 Zn finger	736..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000