DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF484

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	XP_011517375.1	Gene:	ZNF484 / 83744	HGNCID:	23385	Length:	884	Species:	Homo sapiens

Alignment Length:	331	Identity:	95/331 - (28%)
Similarity:	138/331 - (41%)	Gaps:	63/331 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GNYDVCLEDLQLFAQLEDL-------SGER----------------LPMEMELLNPGSEYDLLEL 62
            |||..|.:..:.|.|..||       |||:                |.:..::...|..::..|.
Human   357 GNYYKCSDYGRAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTEC 421

  Fly    63 VNG-------ALQQRNTTEHKPTDMC--------KPKRTPTTKRHRTTGKDHTCDICDRRFSEAY 112
            ...       ::.|:..|..||. :|        :.....|.:|..|..|.:.|..|.:.|.:..
Human   422 GKAFTRKSTLSMHQKIHTGEKPY-VCTECGKAFIRKSHFITHERIHTGEKPYECSDCGKSFIKKS 485

  Fly   113 NLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLH 177
            .|.:|:..||.|.|.:|.||||.|.....|.||...||.|||:.|.:|||.|...:.|..|:::|
Human   486 QLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDRSNLIKHQKIH 550

  Fly   178 TGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVL 242
            ||||||.|  :||..||......|||.|..                    |....:.|..|.:..
Human   551 TGEKPYKC--SDCGKSFTWKSRLRIHQKCH--------------------TGERHYECSECGKAF 593

  Fly   243 TDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHK 307
            ..:..||:|.:.|..::.:.|  .||||.||..|....|:..||.::|:.|.:|...|.:||...
Human   594 IQKSTLSMHQRIHRGEKPYVC--TECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLH 656

  Fly   308 QHLKVH 313
            .|.::|
Human   657 VHQQIH 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	5/19 (26%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	33/112 (29%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	8/20 (40%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF484	XP_011517375.1	KRAB	25..84	CDD:214630
		KRAB	25..64	CDD:279668
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..410	CDD:275368	1/18 (6%)
		zf-H2C2_2	402..427	CDD:290200	3/24 (13%)
		C2H2 Zn finger	418..438	CDD:275368	2/19 (11%)
		zf-H2C2_2	431..455	CDD:290200	5/24 (21%)
		COG5048	442..843	CDD:227381	79/246 (32%)
		C2H2 Zn finger	446..466	CDD:275368	3/19 (16%)
		zf-H2C2_2	458..481	CDD:290200	6/22 (27%)
		C2H2 Zn finger	474..494	CDD:275368	5/19 (26%)
		C2H2 Zn finger	502..522	CDD:275368	9/19 (47%)
		zf-H2C2_2	514..538	CDD:290200	12/23 (52%)
		C2H2 Zn finger	530..550	CDD:275368	7/19 (37%)
		zf-H2C2_2	542..566	CDD:290200	13/25 (52%)
		C2H2 Zn finger	558..578	CDD:275368	9/21 (43%)
		zf-H2C2_2	571..595	CDD:290200	7/43 (16%)
		C2H2 Zn finger	586..606	CDD:275368	5/19 (26%)
		zf-H2C2_2	599..621	CDD:290200	9/23 (39%)
		C2H2 Zn finger	614..634	CDD:275368	9/21 (43%)
		zf-H2C2_2	626..650	CDD:290200	6/23 (26%)
		C2H2 Zn finger	642..662	CDD:275368	6/19 (32%)
		zf-H2C2_2	657..678	CDD:290200	2/6 (33%)
		C2H2 Zn finger	670..690	CDD:275368
		zf-H2C2_2	682..707	CDD:290200
		C2H2 Zn finger	698..718	CDD:275368
		C2H2 Zn finger	726..746	CDD:275368
		zf-H2C2_2	739..763	CDD:290200
		zf-C2H2	752..774	CDD:278523
		C2H2 Zn finger	754..774	CDD:275368
		zf-H2C2_2	766..789	CDD:290200
		C2H2 Zn finger	782..802	CDD:275368
		C2H2 Zn finger	810..830	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000