DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF229

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_055333.3	Gene:	ZNF229 / 7772	HGNCID:	13022	Length:	825	Species:	Homo sapiens

Alignment Length:	242	Identity:	87/242 - (35%)
Similarity:	125/242 - (51%)	Gaps:	33/242 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            :|..|..|.:.|: |.:.|..:.:|.||:..||.|||:.|.|||||||:.:.|..|...||.|||
Human   536 QRLHTGEKPYKCE-CGKSFGRSSDLHIHQRVHTGEKPYKCSECGKGFRRNSDLHSHQRVHTGERP 599

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHS---IHARRIHTKLRHAAQTDPDP 216
            :.||:|||||.|::.|.:|:|:|||||||.|.......|:.|   || :|:||           .
Human   600 YVCDVCGKGFIYSSDLLIHQRVHTGEKPYKCAECGKGFSYSSGLLIH-QRVHT-----------G 652

  Fly   217 EHPLAEQE----QRDTSAL-----------SFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQP 266
            |.|...||    .|.||:|           .:||..|.:..:....|..|.:.|..::.:.|  .
Human   653 EKPYRCQECGKGFRCTSSLHKHQRVHTGKKPYTCDQCGKGFSYGSNLRTHQRLHTGEKPYTC--C 715

  Fly   267 ECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            ||||.|...|.|..|:..||.::|:.|.:|...:.:.|:.:.|.:||
Human   716 ECGKGFRYGSGLLSHKRVHTGEKPYRCHVCGKGYSQSSHLQGHQRVH 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	14/23 (61%)
		COG5048	151..>264	CDD:227381	43/130 (33%)
		C2H2 Zn finger	157..177	CDD:275368	11/19 (58%)
		C2H2 Zn finger	185..206	CDD:275368	8/23 (35%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	4/19 (21%)
ZNF229	NP_055333.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		KRAB	34..>74	CDD:214630
		KRAB	34..73	CDD:279668
		C2H2 Zn finger	351..371	CDD:275368
		COG5048	375..787	CDD:227381	87/242 (36%)
		C2H2 Zn finger	379..399	CDD:275368
		zf-H2C2_2	391..416	CDD:290200
		C2H2 Zn finger	407..427	CDD:275368
		zf-H2C2_2	420..442	CDD:290200
		C2H2 Zn finger	435..455	CDD:275368
		C2H2 Zn finger	463..483	CDD:275368
		zf-H2C2_2	475..500	CDD:290200
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368	1/2 (50%)
		C2H2 Zn finger	547..566	CDD:275368	6/19 (32%)
		zf-H2C2_2	562..583	CDD:290200	13/20 (65%)
		C2H2 Zn finger	574..594	CDD:275368	10/19 (53%)
		zf-H2C2_2	589..611	CDD:290200	13/21 (62%)
		C2H2 Zn finger	602..622	CDD:275368	11/19 (58%)
		zf-H2C2_2	614..639	CDD:290200	11/24 (46%)
		C2H2 Zn finger	630..650	CDD:275368	6/20 (30%)
		zf-H2C2_2	643..667	CDD:290200	9/35 (26%)
		C2H2 Zn finger	658..678	CDD:275368	6/19 (32%)
		zf-H2C2_2	673..695	CDD:290200	3/21 (14%)
		C2H2 Zn finger	686..706	CDD:275368	4/19 (21%)
		zf-H2C2_2	698..723	CDD:290200	9/26 (35%)
		C2H2 Zn finger	714..734	CDD:275368	9/21 (43%)
		zf-H2C2_2	727..751	CDD:290200	7/23 (30%)
		C2H2 Zn finger	742..762	CDD:275368	4/19 (21%)
		zf-H2C2_2	754..779	CDD:290200	3/9 (33%)
		C2H2 Zn finger	770..790	CDD:275368
		zf-H2C2_2	785..807	CDD:290200
		C2H2 Zn finger	798..818	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000