DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF214

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001341759.1	Gene:	ZNF214 / 7761	HGNCID:	13006	Length:	617	Species:	Homo sapiens

Alignment Length:	291	Identity:	93/291 - (31%)
Similarity:	144/291 - (49%)	Gaps:	36/291 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FAQLEDL-SGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKP--TDMCKPKRTPTTKRH-- 92
            |:|:..| :.:|:..|.:......:.||.......:.||.....||  .:.|......::..|
Human   323 FSQISSLHNHQRVHTEEKFYKIECDKDLSRNSLLHIHQRLHIGEKPFKCNQCGKSFNRSSVLHVH 387

  Fly    93 ---RTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
               .|..|.:.||.|.:.||::.|||||::.||.||.:.|.:|||||.|.:.|:||...||.|:|
Human   388 QRVHTGEKPYKCDECGKGFSQSSNLRIHQLVHTGEKSYKCEDCGKGFTQRSNLQIHQRVHTGEKP 452

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHP 219
            :|||.|||.|.:::.|.:|:|:|||||||.|  .:|...|..  :.::||..|  ..|...|
Human   453 YKCDDCGKDFSHSSDLRIHQRVHTGEKPYTC--PECGKGFSK--SSKLHTHQR--VHTGEKP--- 508

  Fly   220 LAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIA 284
                         :.|..|.:..:.:.:|.||.:.|..::.:.|  .:|||.|..:|.|..||..
Human   509 -------------YKCEECGKGFSQRSHLLIHQRVHTGEKPYKC--HDCGKGFSHSSNLHIHQRV 558

  Fly   285 HTQQRPFACPLCPARFLRKSNHKQHLKVHER 315
            ||.::|:.|..|...|    :|...|::|:|
Human   559 HTGEKPYQCAKCGKGF----SHSSALRIHQR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	10/19 (53%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	14/23 (61%)
		COG5048	151..>264	CDD:227381	33/112 (29%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	5/20 (25%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF214	NP_001341759.1	KRAB	14..53	CDD:307490
		COG5048	246..587	CDD:227381	93/291 (32%)
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368	4/12 (33%)
		C2H2 Zn finger	345..363	CDD:275368	4/17 (24%)
		C2H2 Zn finger	371..391	CDD:275368	2/19 (11%)
		C2H2 Zn finger	399..419	CDD:275368	10/19 (53%)
		C2H2 Zn finger	427..447	CDD:275368	10/19 (53%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		C2H2 Zn finger	483..503	CDD:275368	6/25 (24%)
		C2H2 Zn finger	511..531	CDD:275368	5/19 (26%)
		C2H2 Zn finger	539..559	CDD:275368	9/21 (43%)
		C2H2 Zn finger	567..587	CDD:275368	7/23 (30%)
		C2H2 Zn finger	595..614	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000