DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF208

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	241	Identity:	82/241 - (34%)
Similarity:	115/241 - (47%)	Gaps:	30/241 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            ||..|..|.:.|:.|.:.||:...|..||..|..|||:.|.||||.|.:.:.|..|.|.||.|:|
Human   796 KRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKP 860

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARR--IHTKLRHAAQTDPDPE 217
            :||:.|||.:::.:.|:.|:::|||||||.|.......|..||..:.  |||           .|
Human   861 YKCEECGKAYKWPSTLSYHKKIHTGEKPYKCEECGKGFSMFSILTKHEVIHT-----------GE 914

  Fly   218 HPL-AEQEQRDTSALS--------------FTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPE 267
            .|. .|:..:..|.||              :.|..|.:.......||.|.|.|..::  |....|
Human   915 KPYKCEECGKAFSWLSVFSKHKKTHAGEKFYKCEACGKAYKSSSTLSYHKKIHTEEK--PYKYEE 977

  Fly   268 CGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |||.|.:.|.|..|::.||.::|:.|..|...|...||..:|.|:|
Human   978 CGKGFSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKKIH 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	12/23 (52%)
		COG5048	151..>264	CDD:227381	37/129 (29%)
		C2H2 Zn finger	157..177	CDD:275368	6/19 (32%)
		C2H2 Zn finger	185..206	CDD:275368	7/22 (32%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	384..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	555..575	CDD:275368
		zf-H2C2_2	568..592	CDD:290200
		C2H2 Zn finger	583..603	CDD:275368
		zf-H2C2_2	596..619	CDD:290200
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		COG5048	691..1133	CDD:227381	82/241 (34%)
		C2H2 Zn finger	695..715	CDD:275368
		zf-H2C2_2	707..732	CDD:290200
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		zf-H2C2_2	764..788	CDD:290200
		C2H2 Zn finger	779..799	CDD:275368	2/2 (100%)
		C2H2 Zn finger	807..827	CDD:275368	7/19 (37%)
		C2H2 Zn finger	835..855	CDD:275368	9/19 (47%)
		C2H2 Zn finger	863..883	CDD:275368	6/19 (32%)
		zf-H2C2_2	876..899	CDD:290200	10/22 (45%)
		C2H2 Zn finger	891..911	CDD:275368	4/19 (21%)
		C2H2 Zn finger	919..939	CDD:275368	4/19 (21%)
		C2H2 Zn finger	947..967	CDD:275368	6/19 (32%)
		C2H2 Zn finger	976..995	CDD:275368	8/18 (44%)
		C2H2 Zn finger	1003..1023	CDD:275368	7/19 (37%)
		zf-H2C2_2	1015..1039	CDD:290200	4/9 (44%)
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000