Protein Alignment CG2120 and ZNF189

DIOPT Version :9

• Sequence 1: NP_572446.2
• Gene: CG2120 / 31737
• FlyBaseID: FBgn0030005
• Length: 315
• Species: Drosophila melanogaster
• Sequence 2: NP_003443.2
• Gene: ZNF189 / 7743
• HGNCID: 12980
• Length: 626
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 100/351 - (28%)
• Similarity: 142/351 - (40%)
• Gaps: 73/351 - (20%)

  Fly    18 DDLGNYDVCLEDLQLFAQLEDLSG--------ERLPMEMELL---------NPGSE---YDLLEL 62
            |.:|.     |..:|..:|:...|        |.|..|..:.         .|.||   :...|.
Human    94 DPMGR-----ETFELVGRLDKQRGIFLWEIPRESLTQEQRMFRENTNIIRKRPNSEEKCHKCEEC 153

  Fly    63 VNGALQ-------QRNTTEHKP--TDMCKPKRTPTT-----KRHRTTGKDHTCDICDRRFSEAYN 113
            ..|.::       ||..|..||  .:.|....:.::     :|..|..:.:.|:.|.:.||.:..
Human   154 GKGFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSST 218

  Fly   114 LRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHT 178
            |..|:..||.|:|:.|.:|.:.|.|...|..|...||.|:||||..|||.|.:.::|..|:|.||
Human   219 LIRHQRIHTGERPYQCNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHT 283

  Fly   179 GEKPYPCLATDCHLSFHS----IHARRIHTKLRHAAQTDPDPEHP---------------LAEQE 224
            |||||.|  |.|..||..    :..:||||           .|.|               |.:.:
Human   284 GEKPYHC--TKCKKSFSRNSLLVEHQRIHT-----------GERPHKCGECGKAFRLSTYLIQHQ 335

  Fly   225 QRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQR 289
            :..|....|.|..|.:..:...:|..|.:.|..:|.:.|  .||||.|.....|..||..||..:
Human   336 KIHTGEKPFLCIECGKSFSRSSFLIEHQRIHTGERPYQC--KECGKSFSQLCNLTRHQRIHTGDK 398

  Fly   290 PFACPLCPARFLRKSNHKQHLKVHER 315
            |..|..|...|.|.|...||.::|.|
Human   399 PHKCEECGKAFSRSSGLIQHQRIHTR 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	9/24 (38%)
		C2H2 Zn finger	129..149	CDD:275368	6/19 (32%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	39/131 (30%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	9/24 (38%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083
		COG5048	138..524	CDD:227381	91/302 (30%)
		C2H2 Zn finger	150..170	CDD:275368	4/19 (21%)
		C2H2 Zn finger	178..198	CDD:275368	2/19 (11%)
		C2H2 Zn finger	206..226	CDD:275368	6/19 (32%)
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..310	CDD:275368	6/21 (29%)
		C2H2 Zn finger	318..338	CDD:275368	1/19 (5%)
		C2H2 Zn finger	346..366	CDD:275368	4/19 (21%)
		C2H2 Zn finger	374..394	CDD:275368	9/21 (43%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		C2H2 Zn finger	458..478	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		C2H2 Zn finger	514..534	CDD:275368
		zf-H2C2_2	526..551	CDD:404364
		C2H2 Zn finger	542..562	CDD:275368
		zf-H2C2_2	555..579	CDD:404364
		C2H2 Zn finger	570..590	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000