DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF184

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	228	Identity:	80/228 - (35%)
Similarity:	112/228 - (49%)	Gaps:	32/228 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            :|..|..|.:.|:.|::.||.:.||..|:..||.:||:.|.:|||||.:...|..|...||.|:|
Human   241 QRTHTGEKPYKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKP 305

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF----HSIHARRIHTKLRHAAQTDPD 215
            :|||.|||.|....:|..|:|:|||||||.|  .:|..:|    |.:..::|||
Human   306 YKCDECGKAFSQRTHLVQHQRIHTGEKPYTC--NECGKAFSQRGHFMEHQKIHT----------- 357

  Fly   216 PEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKH 280
            .|.|             |.|..|.:..|...:|:.|.|.|..::.:.|  .||||.|...|....
Human   358 GEKP-------------FKCDECDKTFTRSTHLTQHQKIHTGEKTYKC--NECGKAFNGPSTFIR 407

  Fly   281 HQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |.:.||.::|:.|..|...|.:.||..||.|.|
Human   408 HHMIHTGEKPYECNECGKAFSQHSNLTQHQKTH 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	8/19 (42%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	36/116 (31%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	7/24 (29%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212
		C2H2 Zn finger	224..244	CDD:275368	1/2 (50%)
		zf-H2C2_2	236..261	CDD:290200	6/19 (32%)
		COG5048	<248..409	CDD:227381	65/188 (35%)
		C2H2 Zn finger	252..272	CDD:275368	7/19 (37%)
		zf-H2C2_2	264..287	CDD:290200	11/22 (50%)
		C2H2 Zn finger	280..300	CDD:275368	8/19 (42%)
		zf-H2C2_2	292..317	CDD:290200	13/24 (54%)
		C2H2 Zn finger	308..328	CDD:275368	9/19 (47%)
		zf-H2C2_2	320..345	CDD:290200	13/26 (50%)
		C2H2 Zn finger	336..356	CDD:275368	4/21 (19%)
		zf-H2C2_2	348..373	CDD:290200	9/48 (19%)
		COG5048	360..736	CDD:227381	29/96 (30%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-H2C2_2	376..400	CDD:290200	9/25 (36%)
		C2H2 Zn finger	392..412	CDD:275368	8/21 (38%)
		zf-C2H2	418..440	CDD:278523	8/21 (38%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..457	CDD:290200	5/9 (56%)
		C2H2 Zn finger	448..468	CDD:275368
		zf-H2C2_2	460..485	CDD:290200
		C2H2 Zn finger	476..496	CDD:275368
		zf-H2C2_2	488..513	CDD:290200
		C2H2 Zn finger	504..524	CDD:275368
		zf-H2C2_2	516..541	CDD:290200
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
		zf-H2C2_2	628..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000