DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF99

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	278	Identity:	86/278 - (30%)
Similarity:	133/278 - (47%)	Gaps:	29/278 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 MEMELLNPGSE-YDLLELVNGALQQRNTTEHKPTDMCKPKRTPTTKRHRTTGKDHTCDICDRRFS 109
            |:.::::.|.: |...|......|..:.|.||..              .|..|.:.|:.|.:.|:
Human   553 MKHKIIHTGKKPYKCEECGKAFKQSSHLTRHKAI--------------HTGEKPYKCEECGKAFN 603

  Fly   110 EAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHR 174
            ....||.|::.||.:||:.|.||||.|.|.:.||.|.:.||.|:|:||:.|||.|:::::||.|:
Human   604 HFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHLTRHK 668

  Fly   175 RLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDPEH---------PLAEQEQRDTSA 230
            .:||.||||.|  .:|..:|:...|.|.| |:.|..:.....|.         .|.:.|...|..
Human   669 VIHTEEKPYKC--EECGKAFNHFSALRKH-KIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGE 730

  Fly   231 LSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPL 295
            ..:.|..|.:.......|::|...|..::  ||...||||.|...|.|:.|:|.||.::|:.|..
Human   731 KPYKCEECGKAFKWSSKLTVHKVIHTAEK--PCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEE 793

  Fly   296 CPARFLRKSNHKQHLKVH 313
            |...|...|..::|..:|
Human   794 CGKAFNNSSTLRKHEIIH 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	35/121 (29%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	6/20 (30%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		COG5048	267..684	CDD:227381	51/146 (35%)
		zf-H2C2_2	272..296	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..352	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		zf-H2C2_2	383..407	CDD:290200
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..491	CDD:290200
		C2H2 Zn finger	483..503	CDD:275368
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		COG5048	534..857	CDD:227381	86/278 (31%)
		C2H2 Zn finger	539..559	CDD:275368	1/5 (20%)
		zf-H2C2_2	552..576	CDD:290200	4/22 (18%)
		C2H2 Zn finger	567..587	CDD:275368	5/33 (15%)
		zf-H2C2_2	579..604	CDD:290200	8/38 (21%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		zf-H2C2_2	607..632	CDD:290200	13/24 (54%)
		C2H2 Zn finger	623..643	CDD:275368	10/19 (53%)
		zf-H2C2_2	636..659	CDD:290200	12/22 (55%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		zf-H2C2_2	663..688	CDD:290200	12/26 (46%)
		C2H2 Zn finger	679..699	CDD:275368	7/22 (32%)
		zf-H2C2_2	691..716	CDD:290200	6/25 (24%)
		C2H2 Zn finger	707..727	CDD:275368	3/19 (16%)
		zf-H2C2_2	720..743	CDD:290200	5/22 (23%)
		C2H2 Zn finger	735..755	CDD:275368	4/19 (21%)
		C2H2 Zn finger	763..783	CDD:275368	9/19 (47%)
		zf-H2C2_2	775..800	CDD:290200	9/24 (38%)
		C2H2 Zn finger	791..811	CDD:275368	5/19 (26%)
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000