DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF708

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	XP_016882693.1	Gene:	ZNF708 / 7562	HGNCID:	12945	Length:	587	Species:	Homo sapiens

Alignment Length:	316	Identity:	99/316 - (31%)
Similarity:	143/316 - (45%)	Gaps:	43/316 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDLSGERLPMEMELLNPGSE-YDLLELVNGALQQRNTTEHK---------PTDM 80
            |.|..:.|..|..|:      :.|:::.|.: |...|......:..|.|.||         ..:.
Human   170 CKECGKSFCMLSQLT------QHEIIHTGEKPYKCEECGKAFKKSSNLTNHKIIHTGEKPYKCEE 228

  Fly    81 CKP--KRTPTTKRHR---TTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLN 140
            |..  .::.|..||:   |..|.:.|:.|.:.|:.:.||..||:.||.|||:.|.||||.|:|.:
Human   229 CGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSS 293

  Fly   141 KLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF--------HSI 197
            .|..|...||.|:|:||..|||.|..:::||.|:|:|||||||.|  .:|..:|        |.|
Human   294 NLTNHKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTGEKPYKC--EECGKAFSVFSTLTKHKI 356

  Fly   198 HARRIHT-----KLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYN 257
                |||     |.....:......| |...:...|....:.|..|.:..|....|:.|...|..
Human   357 ----IHTEEKPYKCEECGKAFNRSSH-LTNHKVIHTGEKPYKCEECGKAFTKSSTLTYHKVIHTG 416

  Fly   258 QRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            ::.:.|  .||||.|...|.|..|::.||:.:|:.|..|...|...||...|.|:|
Human   417 KKPYKC--EECGKAFSIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFTNHKKIH 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	12/23 (52%)
		COG5048	151..>264	CDD:227381	37/125 (30%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	8/33 (24%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
ZNF708	XP_016882693.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000