Protein Alignment CG2120 and YY1

DIOPT Version :10

• Sequence 1: NP_572446.2
• Gene: CG2120 / 31737
• FlyBaseID: FBgn0030005
• Length: 315
• Species: Drosophila melanogaster
• Sequence 2: NP_003394.1
• Gene: YY1 / 7528
• HGNCID: 12856
• Length: 414
• Species: Homo sapiens
• Alignment Length: 182
• Identity: 55/182 - (30%)
• Similarity: 78/182 - (42%)
• Gaps: 35/182 - (19%)

  Fly    37 EDLSGERLPMEMELLNPGS--EYDLLELVNGALQQRNTTEHKPTDMC-----KPKRTPTTKRHRT 94
            |.::|::||       ||.  ..||.:               |..:.     ||::.......||
Human   253 EYMTGKKLP-------PGGIPGIDLSD---------------PKQLAEFARMKPRKIKEDDAPRT 295

  Fly    95 TGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERPHKCDI 159
            ....|..  |.:.|.:...:|.|..|| ..:.|||.||||.|.:.:||:.|.:.||.|:|.:|..
Human   296 IACPHKG--CTKMFRDNSAMRKHLHTH-GPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTF 357

  Fly   160 --CGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHA 209
              |||.|.....|..|.|:|||::||.|....|:..|......:.|. |.||
Human   358 EGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHI-LTHA 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	4/19 (21%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		COG5048	151..>264	CDD:227381	22/61 (36%)
		C2H2 Zn finger	157..177	CDD:275368	8/21 (38%)
		C2H2 Zn finger	185..206	CDD:275368	4/20 (20%)
		C2H2 Zn finger	235..255	CDD:275368
		C2H2 Zn finger	263..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368
YY1	NP_003394.1	Interaction with the SMAD1/SMAD4 complex. /evidence=ECO:0000269|PubMed:15329343	1..170
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	33..81
		Gly-rich region involved in interaction with HCFC1. /evidence=ECO:0000269|PubMed:20805357	116..260		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..203
		Involved in nuclear matrix association. /evidence=ECO:0000269|PubMed:9493912	257..341		28/108 (26%)
		COG5048	<268..407	CDD:227381	47/157 (30%)
		Binding to DNA. /evidence=ECO:0000269|PubMed:18950698	295..414		43/118 (36%)
		C2H2 Zn finger	298..320	CDD:275368	5/23 (22%)
		C2H2 Zn finger	327..347	CDD:275368	9/19 (47%)
		Involved in repression of activated transcription	333..371		13/37 (35%)
		C2H2 Zn finger	355..377	CDD:275368	8/21 (38%)
		Involved in masking transactivation domain	371..397		10/25 (40%)
		C2H2 Zn finger	385..407	CDD:275368	5/22 (23%)