DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZFP62

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001166109.1	Gene:	ZFP62 / 643836	HGNCID:	23241	Length:	900	Species:	Homo sapiens

Alignment Length:	273	Identity:	85/273 - (31%)
Similarity:	118/273 - (43%)	Gaps:	62/273 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGF----RQLNKLRI------ 144
            ||..|..|.:.||||.:.||.:..||:||..||.|||:.|.||||.|    ..||...|
Human   272 KRIHTGEKPYECDICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKP 336

  Fly   145 ------------------HAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCH 191
                              |.|.||.|:|::||.|||.||.::.|.||:|:|||||||.|  ..|.
Human   337 YKCDECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTGEKPYKC--DVCG 399

  Fly   192 LSFHSIHARRIHTKLRHAAQTDPDPEHP-------------------LAEQEQRDTSALSFTCPV 237
            .:|.......:|..:           ||                   |.:.....|....:.|.|
Human   400 KAFSYSSGLAVHKSI-----------HPGKKAHECKECGKSFSYNSLLLQHRTIHTGERPYVCDV 453

  Fly   238 CSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLR 302
            |.:...:...|.:|.:.|..::.:.|  ..|||.:.|.|.||:|:..|..::|:.|..|...|..
Human   454 CGKTFRNNAGLKVHRRLHTGEKPYKC--DVCGKAYISRSSLKNHKGIHLGEKPYKCSYCEKSFNY 516

  Fly   303 KSNHKQHLKVHER 315
            .|..:||.::|.|
Human   517 SSALEQHKRIHTR 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	10/19 (53%)
		zf-H2C2_2	113..138	CDD:290200	15/28 (54%)
		C2H2 Zn finger	129..149	CDD:275368	11/47 (23%)
		zf-H2C2_2	142..166	CDD:290200	13/47 (28%)
		COG5048	151..>264	CDD:227381	34/131 (26%)
		C2H2 Zn finger	157..177	CDD:275368	11/19 (58%)
		C2H2 Zn finger	185..206	CDD:275368	4/20 (20%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZFP62	NP_001166109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		COG5048	125..552	CDD:227381	85/273 (31%)
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..247	CDD:275368
		C2H2 Zn finger	255..275	CDD:275368	2/2 (100%)
		C2H2 Zn finger	283..303	CDD:275368	10/19 (53%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	2/19 (11%)
		C2H2 Zn finger	367..387	CDD:275368	11/19 (58%)
		C2H2 Zn finger	395..415	CDD:275368	4/32 (13%)
		C2H2 Zn finger	423..443	CDD:275368	1/19 (5%)
		COG5048	447..860	CDD:227381	25/85 (29%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	9/21 (43%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..834	CDD:275368
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000