DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and Zfp997

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001171303.1	Gene:	Zfp997 / 628709	MGIID:	3642406	Length:	604	Species:	Mus musculus

Alignment Length:	275	Identity:	92/275 - (33%)
Similarity:	130/275 - (47%)	Gaps:	49/275 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QRNTTEHKPTDMCKPKRTPTTKRH-----RT-TG-KDHTCDICDRRFSEAYNLRIHKMTHTDEKP 126
            :|..|..||.:..:..::..|.||     || || |.:.|:.|.:.|:.:.:|:.||.|||.|||
Mouse   318 KRTHTGEKPYECNQCGKSFATSRHLQCHKRTHTGEKPYECNQCGKAFATSSHLQCHKRTHTGEKP 382

  Fly   127 HVCVECGKGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPC------ 185
            :.|.:|||.|...:.||.|..|||.|:|::|:.|||.|....||..|:|.|||||||.|
Mouse   383 YECNQCGKAFSCHSGLRHHKRTHTGEKPYECNQCGKAFSRPAYLQHHKRTHTGEKPYECNQCGKA 447

  Fly   186 LATDCHLSFHSIHARRIHTKLRHAAQTDPDPEHP---------------LAEQEQRDTSALSFTC 235
            .|...||..|    :|.||           .|.|               |...::..|....:.|
Mouse   448 FAKPSHLQCH----KRTHT-----------GEKPFECNQCGKAFSCYNSLRYHKRTHTGEKLYEC 497

  Fly   236 PVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARF 300
            ..|.:......:|..|.:.|..::.:.|.|  |||.|.::|.|..|:..||.::||.|..|...|
Mouse   498 NQCGKAFATSSHLQCHKRTHTGEKPYECNQ--CGKAFATSSHLHCHKRTHTGEKPFECNQCGKAF 560

  Fly   301 LRKSNHKQHLKVHER 315
            .|.|    ||::|:|
Mouse   561 ARPS----HLQIHKR 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	14/24 (58%)
		C2H2 Zn finger	129..149	CDD:275368	8/19 (42%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	35/133 (26%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	8/26 (31%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
Zfp997	NP_001171303.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	77..97	CDD:275368
		zf-H2C2_2	89..114	CDD:290200
		C2H2 Zn finger	105..125	CDD:275368
		zf-H2C2_2	118..142	CDD:290200
		COG5048	129..564	CDD:227381	87/262 (33%)
		C2H2 Zn finger	133..153	CDD:275368
		zf-H2C2_2	145..170	CDD:290200
		C2H2 Zn finger	161..181	CDD:275368
		zf-H2C2_2	173..198	CDD:290200
		C2H2 Zn finger	189..209	CDD:275368
		zf-H2C2_2	202..226	CDD:290200
		C2H2 Zn finger	217..237	CDD:275368
		zf-H2C2_2	229..254	CDD:290200
		C2H2 Zn finger	245..265	CDD:275368
		zf-H2C2_2	258..282	CDD:290200
		C2H2 Zn finger	273..293	CDD:275368
		zf-H2C2_2	286..310	CDD:290200
		C2H2 Zn finger	301..321	CDD:275368	1/2 (50%)
		zf-H2C2_2	314..338	CDD:290200	4/19 (21%)
		C2H2 Zn finger	329..349	CDD:275368	4/19 (21%)
		zf-H2C2_2	341..366	CDD:290200	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	369..394	CDD:290200	14/24 (58%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	398..422	CDD:290200	13/23 (57%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		zf-H2C2_2	425..449	CDD:290200	12/23 (52%)
		C2H2 Zn finger	441..461	CDD:275368	6/23 (26%)
		zf-H2C2_2	453..478	CDD:290200	8/39 (21%)
		C2H2 Zn finger	469..489	CDD:275368	1/19 (5%)
		C2H2 Zn finger	497..517	CDD:275368	4/19 (21%)
		zf-H2C2_2	509..534	CDD:290200	9/26 (35%)
		C2H2 Zn finger	525..545	CDD:275368	9/21 (43%)
		C2H2 Zn finger	553..573	CDD:275368	9/23 (39%)
		zf-H2C2_2	565..590	CDD:290200	4/7 (57%)
		C2H2 Zn finger	581..601	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000