DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and Zfp268

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001311345.1	Gene:	Zfp268 / 433801	MGIID:	3651014	Length:	799	Species:	Mus musculus

Alignment Length:	331	Identity:	99/331 - (29%)
Similarity:	138/331 - (41%)	Gaps:	73/331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDLSGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCKPKRTPTTK 90
            |.|..:.|.|..||:                          :.||..|..||....:..:..|.|
Mouse   380 CSECDKCFTQKSDLN--------------------------IHQRIHTGEKPYKCSECDKCFTHK 418

  Fly    91 RH-------RTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVT 148
            .|       .|..|.:.|..||:.|:..::|.||:..||.|.|:.|.||.|.|.|.:.|.||...
Mouse   419 SHLNSHQRIHTGEKPYKCSECDKCFTRKFHLSIHQRIHTGENPYKCSECDKCFTQKSDLNIHQRI 483

  Fly   149 HTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATD-C-----HLSFHS-IH-------- 198
            ||.|:|:||..|.|.|.:.::|..|:|:|||||||.|...| |     |||.|. ||
Mouse   484 HTGEKPYKCSECDKCFTHKSHLNSHQRIHTGEKPYKCSECDKCFTRKFHLSIHQRIHTGEKPYKC 548

  Fly   199 -------ARRIHTKLRHAAQTDPDP------------EHPLAEQEQRDTSALSFTCPVCSRVLTD 244
                   .|:.|..:.....|..:|            :..|:..::..|....:.|..|.:..|.
Mouse   549 SECDKCFTRKFHLSIHQRIHTGENPYKCSECDKCFTRKFHLSIHQRIHTGEKPYKCSECDKCFTR 613

  Fly   245 QCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQH 309
            :.:||||.:.|..:..:.|  .||.|.|...|:|..||..||.::|:.|..|...|    .||.|
Mouse   614 KFHLSIHQRIHTGENPYKC--SECDKCFTQKSDLNIHQRIHTGEKPYKCSECDKCF----THKSH 672

  Fly   310 LKVHER 315
            |..|:|
Mouse   673 LNSHQR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	12/23 (52%)
		COG5048	151..>264	CDD:227381	40/146 (27%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	11/42 (26%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
Zfp268	NP_001311345.1	KRAB	12..52	CDD:366587
		C2H2 Zn finger	184..204	CDD:275368
		C2H2 Zn finger	216..232	CDD:275368
		C2H2 Zn finger	240..260	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		COG5048	320..717	CDD:227381	99/331 (30%)
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368	8/45 (18%)
		C2H2 Zn finger	408..428	CDD:275368	3/19 (16%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	2/19 (11%)
		C2H2 Zn finger	576..596	CDD:275368	1/19 (5%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		C2H2 Zn finger	632..652	CDD:275368	9/21 (43%)
		C2H2 Zn finger	660..680	CDD:275368	9/23 (39%)
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000