DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF470

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001001668.3	Gene:	ZNF470 / 388566	HGNCID:	22220	Length:	717	Species:	Homo sapiens

Alignment Length:	321	Identity:	91/321 - (28%)
Similarity:	146/321 - (45%)	Gaps:	52/321 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDLSGERLPMEMELLNPGSE-YDLLELVNGALQQRNTTEH--------KPTD-- 79
            |:|..:.|:....|:..|      .::.|.. |:.::......|..:...|        ||.|
Human   342 CIECGKAFSDCSSLAHHR------RIHTGKRPYECIDCGKAFRQNASLIRHRRYYHTGEKPFDCI 400

  Fly    80 -----------MCKPKRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECG 133
                       :.:.|||.|.:|      .:.|::|.:.||...:|.:|:..||.|||:.|..|.
Human   401 DCGKAFTDHIGLIQHKRTHTGER------PYKCNVCGKAFSHGSSLTVHQRIHTGEKPYECNICE 459

  Fly   134 KGFRQLNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF---- 194
            |.|.....|.:|...||.|:|::|..|||.||.:.:|..|:|:|||||||.|  .:|..:|
Human   460 KAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKPYEC--KECSKTFSQNA 522

  Fly   195 HSIHARRIHT-----KLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKR 254
            |....::|||     :.:...:......| |.:.::..|....:.|..|.:..:|..||..|.:.
Human   523 HLAQHQKIHTGEKPYECKECGKAFSQIAH-LVQHQRVHTGEKPYECIECGKAFSDGSYLVQHQRL 586

  Fly   255 HYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVHER 315
            |..:|.:.|  .||||.|...:.|..||..||.::|:.|.:|...|    :|::.|.:|:|
Human   587 HSGKRPYEC--LECGKAFRQRASLICHQRCHTGEKPYECNVCGKAF----SHRKSLTLHQR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	11/24 (46%)
		C2H2 Zn finger	129..149	CDD:275368	6/19 (32%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	36/121 (30%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	7/29 (24%)
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF470	NP_001001668.3	KRAB	23..83	CDD:214630
		KRAB	23..62	CDD:279668
		Nuclear localization signal. /evidence=ECO:0000255	216..219
		C2H2 Zn finger	230..250	CDD:275368
		zf-H2C2_2	243..267	CDD:290200
		COG5048	254..669	CDD:227381	91/321 (28%)
		C2H2 Zn finger	258..278	CDD:275368
		zf-H2C2_2	270..295	CDD:290200
		C2H2 Zn finger	286..306	CDD:275368
		zf-H2C2_2	298..323	CDD:290200
		C2H2 Zn finger	314..334	CDD:275368
		zf-H2C2_2	326..350	CDD:290200	2/7 (29%)
		C2H2 Zn finger	342..362	CDD:275368	5/25 (20%)
		zf-H2C2_2	354..379	CDD:290200	4/30 (13%)
		C2H2 Zn finger	370..388	CDD:275368	2/17 (12%)
		Nuclear localization signal. /evidence=ECO:0000255	385..388		1/2 (50%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		zf-H2C2_2	412..436	CDD:290200	8/29 (28%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..492	CDD:290200	11/24 (46%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		zf-H2C2_2	495..520	CDD:290200	13/26 (50%)
		C2H2 Zn finger	511..531	CDD:275368	4/21 (19%)
		zf-H2C2_2	523..548	CDD:290200	4/24 (17%)
		C2H2 Zn finger	539..559	CDD:275368	2/20 (10%)
		zf-H2C2_2	551..575	CDD:290200	5/24 (21%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
		C2H2 Zn finger	595..615	CDD:275368	9/21 (43%)
		zf-H2C2_2	607..632	CDD:290200	9/28 (32%)
		C2H2 Zn finger	623..643	CDD:275368	7/23 (30%)
		zf-H2C2_2	635..660	CDD:290200	3/7 (43%)
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000