Protein Alignment CG2120 and ZNF728

DIOPT Version :9

• Sequence 1: NP_572446.2
• Gene: CG2120 / 31737
• FlyBaseID: FBgn0030005
• Length: 315
• Species: Drosophila melanogaster
• Sequence 2: NP_001254645.1
• Gene: ZNF728 / 388523
• HGNCID: 32463
• Length: 622
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 80/255 - (31%)
• Similarity: 116/255 - (45%)
• Gaps: 45/255 - (17%)

  Fly    85 RTPTTKRHRTT---GKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHA 146
            :..|...|:|.   .|.:.|:.|.:.|:.:.||..||..||.|||..|.||||.|...:.|..|.
Human   295 KASTLTAHKTIHAGEKPYKCEECGKAFNRSSNLMEHKRIHTGEKPCKCEECGKAFGNFSTLTKHK 359

  Fly   147 VTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF--------HSIHARRIH 203
            |.||.|:|:||:.|||.|.:.:.||.|:|:|.|:|||.|  .:|..:|        |.|    ||
Human   360 VIHTGEKPYKCEECGKAFSWPSSLTEHKRIHAGDKPYKC--EECGKTFKWSSTLTKHKI----IH 418

  Fly   204 TKLRHAAQTDPDPEHP---------------LAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLK 253
            |           .|.|               |.:.:...|....:.|..|.:|.:....|:.|..
Human   419 T-----------GEKPYKCEECGKAFTTFSSLTKHKVIHTGEKHYKCEECGKVFSWSSSLTTHKA 472

  Fly   254 RHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            .|..::.:.|  .||||.|..:|.|..|:..||.::|:.|..|...|.:.:|..:|..:|
Human   473 IHAGEKLYKC--EECGKAFKWSSNLMEHKRIHTGEKPYKCEECGKAFSKVANLTKHKVIH 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	13/23 (57%)
		COG5048	151..>264	CDD:227381	35/135 (26%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	8/28 (29%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	186..583	CDD:227381	80/255 (31%)
		C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	258..278	CDD:275368
		C2H2 Zn finger	286..306	CDD:275368	3/10 (30%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		zf-H2C2_2	326..349	CDD:290200	14/22 (64%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		zf-H2C2_2	355..378	CDD:290200	12/22 (55%)
		C2H2 Zn finger	370..390	CDD:275368	9/19 (47%)
		zf-H2C2_2	382..406	CDD:290200	11/25 (44%)
		C2H2 Zn finger	398..418	CDD:275368	5/25 (20%)
		zf-H2C2_2	411..435	CDD:290200	7/38 (18%)
		C2H2 Zn finger	426..446	CDD:275368	1/19 (5%)
		C2H2 Zn finger	454..474	CDD:275368	5/19 (26%)
		C2H2 Zn finger	482..502	CDD:275368	9/21 (43%)
		zf-H2C2_2	494..518	CDD:290200	7/23 (30%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		zf-H2C2_2	522..545	CDD:290200	3/9 (33%)
		C2H2 Zn finger	538..558	CDD:275368
		zf-H2C2_2	551..574	CDD:290200
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910