DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF568

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	295	Identity:	89/295 - (30%)
Similarity:	134/295 - (45%)	Gaps:	57/295 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDL-------SGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKPTDMCKP 83
            |.|..:.|.|:.:|       :||:            .|...:......|:.|..||
Human   280 CNECGKAFIQMSNLIRHHRIHTGEK------------PYACKDCWKAFSQKSNLIEH-------- 324

  Fly    84 KRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVT 148
                  :|..|..|.:.|..|.:.||:..||..|:..||.|||:.|.|||:.|.:::.:.:|..:
Human   325 ------ERIHTGEKPYECKECGKSFSQKQNLIEHEKIHTGEKPYACNECGRAFSRMSSVTLHMRS 383

  Fly   149 HTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTD 213
            ||.|:|:||:.|||.|...:...:|.|.|||||||.|  ::|..:|....:..:|.: .|.|
Human   384 HTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEKPYVC--SECGKAFSQSSSLTVHMR-NHTA--- 442

  Fly   214 PDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASEL 278
               |.|             :.|..|.:..:.:..|..|.|.|..::.:.|  .||||.|...|.|
Human   443 ---EKP-------------YECKECGKAFSRKENLITHQKIHTGEKPYEC--SECGKAFIQMSNL 489

  Fly   279 KHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            ..||..||.::|:||.:|...|.:|||..:|.|:|
Human   490 IRHQRIHTGEKPYACTVCGKAFSQKSNLTEHEKIH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/19 (37%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	6/19 (32%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	31/112 (28%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	4/20 (20%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368
		zf-H2C2_2	236..261	CDD:290200
		COG5048	248..634	CDD:227381	89/295 (30%)
		C2H2 Zn finger	252..272	CDD:275368
		zf-H2C2_2	264..289	CDD:290200	3/8 (38%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		zf-H2C2_2	292..317	CDD:290200	4/36 (11%)
		C2H2 Zn finger	308..328	CDD:275368	5/33 (15%)
		zf-H2C2_2	320..345	CDD:290200	9/38 (24%)
		C2H2 Zn finger	336..356	CDD:275368	7/19 (37%)
		zf-H2C2_2	348..373	CDD:290200	13/24 (54%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		zf-H2C2_2	380..401	CDD:290200	11/20 (55%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		zf-H2C2_2	408..429	CDD:290200	12/22 (55%)
		C2H2 Zn finger	420..440	CDD:275368	4/22 (18%)
		zf-H2C2_2	432..457	CDD:290200	7/44 (16%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		zf-H2C2_2	460..485	CDD:290200	10/26 (38%)
		C2H2 Zn finger	476..496	CDD:275368	10/21 (48%)
		zf-H2C2_2	488..513	CDD:290200	10/24 (42%)
		C2H2 Zn finger	504..524	CDD:275368	8/19 (42%)
		zf-H2C2_2	516..541	CDD:290200	4/9 (44%)
		C2H2 Zn finger	532..552	CDD:275368
		zf-H2C2_2	544..569	CDD:290200
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	601..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000