DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2120 and ZNF680

DIOPT Version :9

Sequence 1:NP_572446.2 Gene:CG2120 / 31737 FlyBaseID:FBgn0030005 Length:315 Species:Drosophila melanogaster
Sequence 2:NP_848653.2 Gene:ZNF680 / 340252 HGNCID:26897 Length:530 Species:Homo sapiens


Alignment Length:228 Identity:75/228 - (32%)
Similarity:109/228 - (47%) Gaps:32/228 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            ||..|..|...|:.|.:.|::..||..||..||.|||:.|.||||.|.|...|..|...||.|:.
Human   313 KRIHTGEKPFKCEECGKDFNQFSNLTKHKKIHTGEKPYKCEECGKAFNQFANLTRHKKIHTGEKS 377

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHA----RRIHTKLRHAAQTDPD 215
            :||:.|||.|..::.||.|.|:|||||||.|  .:|..:|:...:    :||||:..        
Human   378 YKCEECGKAFIQSSNLTEHMRIHTGEKPYKC--EECGKAFNGCSSLTRHKRIHTREN-------- 432

  Fly   216 PEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKH 280
                            ::.|..|.:..|....|:.|...|..::.:.|  .|||..|...:.|.:
Human   433 ----------------TYKCEECGKGFTLFSTLTNHKVIHTGEKSYKC--DECGNVFNWPATLAN 479

  Fly   281 HQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |:..|.:::|:.|..|...|.|.|:..:|.|:|
Human   480 HKRIHAREKPYKCEECGKAFNRSSHLTRHKKIH 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2120NP_572446.2 C2H2 Zn finger 101..121 CDD:275368 7/19 (37%)
zf-H2C2_2 113..138 CDD:290200 15/24 (63%)
C2H2 Zn finger 129..149 CDD:275368 9/19 (47%)
zf-H2C2_2 142..166 CDD:290200 11/23 (48%)
COG5048 151..>264 CDD:227381 31/116 (27%)
C2H2 Zn finger 157..177 CDD:275368 9/19 (47%)
C2H2 Zn finger 185..206 CDD:275368 7/24 (29%)
C2H2 Zn finger 235..255 CDD:275368 5/19 (26%)
C2H2 Zn finger 263..285 CDD:275368 7/21 (33%)
C2H2 Zn finger 293..313 CDD:275368 7/19 (37%)
ZNF680NP_848653.2 KRAB 13..73 CDD:214630
KRAB 13..52 CDD:279668
COG5048 152..513 CDD:227381 75/228 (33%)
zf-C2H2 182..204 CDD:278523
C2H2 Zn finger 184..204 CDD:275368
C2H2 Zn finger 212..232 CDD:275368
zf-H2C2_2 224..249 CDD:290200
C2H2 Zn finger 240..260 CDD:275368
zf-H2C2_2 253..276 CDD:290200
C2H2 Zn finger 268..288 CDD:275368
zf-H2C2_2 281..304 CDD:290200
C2H2 Zn finger 296..316 CDD:275368 2/2 (100%)
zf-H2C2_2 309..333 CDD:290200 7/19 (37%)
C2H2 Zn finger 324..344 CDD:275368 7/19 (37%)
zf-H2C2_2 336..361 CDD:290200 15/24 (63%)
C2H2 Zn finger 352..372 CDD:275368 9/19 (47%)
zf-H2C2_2 364..389 CDD:290200 11/24 (46%)
C2H2 Zn finger 380..400 CDD:275368 9/19 (47%)
zf-H2C2_2 392..416 CDD:290200 13/25 (52%)
C2H2 Zn finger 408..428 CDD:275368 4/21 (19%)
C2H2 Zn finger 436..456 CDD:275368 5/19 (26%)
C2H2 Zn finger 464..484 CDD:275368 7/21 (33%)
zf-H2C2_2 477..501 CDD:290200 7/23 (30%)
zf-C2H2 490..512 CDD:278523 7/21 (33%)
C2H2 Zn finger 492..512 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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