DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2120 and ZNF678

DIOPT Version :9

Sequence 1:NP_572446.2 Gene:CG2120 / 31737 FlyBaseID:FBgn0030005 Length:315 Species:Drosophila melanogaster
Sequence 2:NP_848644.2 Gene:ZNF678 / 339500 HGNCID:28652 Length:580 Species:Homo sapiens


Alignment Length:306 Identity:93/306 - (30%)
Similarity:143/306 - (46%) Gaps:40/306 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 QLFAQLEDLSGERLPMEMELLNPGSEYDLLELVNGALQQRNTTEHKP----------TDMCKP-- 83
            ||.:..:..|||:            .|...|......|..|.|:||.          .:.||.  
Human   250 QLTSHKKIHSGEK------------PYPCEECGKAFTQFSNLTQHKRIHTGEKPYKCKECCKAFN 302

  Fly    84 KRTPTT--KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHA 146
            |.:..|  ||..|..|.:.|:.|...|:|..:|..|:..||.|||:.|.||||.|.|...|..|.
Human   303 KFSNLTQHKRIHTGEKPYKCEECGNVFNECSHLTRHRRIHTGEKPYKCEECGKAFTQFASLTRHK 367

  Fly   147 VTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSF----HSIHARRIHT--- 204
            ..||.|:|::|:.|||.|...::|:.|:|:|||||||.|  .:|..:|    :....:||||   
Human   368 RIHTGEKPYQCEECGKTFNRCSHLSSHKRIHTGEKPYKC--EECGRTFTQFSNLTQHKRIHTGEK 430

  Fly   205 --KLRHAAQTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPE 267
              |.:...:.. :....|.:..:..|....:.|..|.:|.....:|:.|.:.|..::.:.|  .|
Human   431 PYKCKECGKAF-NKFSSLTQHRRIHTGVKPYKCEECGKVFKQCSHLTSHKRIHTGEKPYKC--KE 492

  Fly   268 CGKRFFSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            |||.|:.:|.|..|:..||:::|:.|..|...|.:.|:..:|.::|
Human   493 CGKAFYQSSILSKHKRIHTEEKPYKCEECGKAFNQFSSLTRHKRIH 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2120NP_572446.2 C2H2 Zn finger 101..121 CDD:275368 6/19 (32%)
zf-H2C2_2 113..138 CDD:290200 13/24 (54%)
C2H2 Zn finger 129..149 CDD:275368 9/19 (47%)
zf-H2C2_2 142..166 CDD:290200 11/23 (48%)
COG5048 151..>264 CDD:227381 33/121 (27%)
C2H2 Zn finger 157..177 CDD:275368 8/19 (42%)
C2H2 Zn finger 185..206 CDD:275368 7/29 (24%)
C2H2 Zn finger 235..255 CDD:275368 5/19 (26%)
C2H2 Zn finger 263..285 CDD:275368 9/21 (43%)
C2H2 Zn finger 293..313 CDD:275368 5/19 (26%)
ZNF678NP_848644.2 KRAB 44..101 CDD:214630
KRAB 44..83 CDD:279668
COG5048 138..536 CDD:227381 92/302 (30%)
C2H2 Zn finger 154..174 CDD:275368
zf-H2C2_2 167..191 CDD:290200
C2H2 Zn finger 182..202 CDD:275368
zf-H2C2_2 194..218 CDD:290200
C2H2 Zn finger 210..230 CDD:275368
zf-H2C2_2 223..246 CDD:290200
C2H2 Zn finger 238..258 CDD:275368 2/7 (29%)
zf-H2C2_2 251..275 CDD:290200 6/35 (17%)
C2H2 Zn finger 266..286 CDD:275368 6/19 (32%)
zf-H2C2_2 278..302 CDD:290200 6/23 (26%)
C2H2 Zn finger 294..314 CDD:275368 6/19 (32%)
zf-H2C2_2 306..330 CDD:290200 7/23 (30%)
C2H2 Zn finger 322..342 CDD:275368 6/19 (32%)
zf-H2C2_2 334..359 CDD:290200 13/24 (54%)
C2H2 Zn finger 350..370 CDD:275368 9/19 (47%)
zf-H2C2_2 362..387 CDD:290200 11/24 (46%)
C2H2 Zn finger 378..398 CDD:275368 8/19 (42%)
zf-H2C2_2 390..415 CDD:290200 13/26 (50%)
C2H2 Zn finger 406..426 CDD:275368 4/21 (19%)
zf-H2C2_2 418..442 CDD:290200 5/24 (21%)
C2H2 Zn finger 434..454 CDD:275368 1/20 (5%)
zf-H2C2_2 446..471 CDD:290200 5/24 (21%)
C2H2 Zn finger 462..482 CDD:275368 5/19 (26%)
zf-H2C2_2 474..497 CDD:290200 8/24 (33%)
C2H2 Zn finger 490..510 CDD:275368 9/21 (43%)
zf-H2C2_2 503..527 CDD:290200 8/23 (35%)
C2H2 Zn finger 518..538 CDD:275368 5/19 (26%)
zf-H2C2_2 530..553 CDD:290200 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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