DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF546

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_848639.2	Gene:	ZNF546 / 339327	HGNCID:	28671	Length:	836	Species:	Homo sapiens

Alignment Length:	236	Identity:	80/236 - (33%)
Similarity:	115/236 - (48%)	Gaps:	20/236 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQLNKLRIHAVTHTAERP 154
            :|..|:...:.|..|.:.||..|||..|...||.|||::|.||||.||...:|..|...||.|:|
Human   572 QRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKP 636

  Fly   155 HKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAAQTDPDP--- 216
            :||..|||.|..:.:||.|.|:|||||||.|  |:|..:|    :|..|....|...|...|
Human   637 YKCTECGKAFIRSTHLTQHHRIHTGEKPYEC--TECGKTF----SRHYHLTQHHRGHTGEKPYIC 695

  Fly   217 ---------EHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRF 272
                     .:.|...::..|..|.:.|..|.:..:.:.:|:.|.:.|..::.:.|  .|||..|
Human   696 NECGNAFICSYRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSC--KECGNAF 758

  Fly   273 FSASELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            ...:||..|.|.||.::|:.|..|...|...|...:|.::|
Human   759 RLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHRIH 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	113..138	CDD:290200	14/24 (58%)
		C2H2 Zn finger	129..149	CDD:275368	9/19 (47%)
		zf-H2C2_2	142..166	CDD:290200	12/23 (52%)
		COG5048	151..>264	CDD:227381	36/124 (29%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	6/20 (30%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
ZNF546	NP_848639.2	KRAB	60..120	CDD:214630
		KRAB	60..99	CDD:279668
		COG5048	<215..375	CDD:227381
		C2H2 Zn finger	219..239	CDD:275368
		zf-H2C2_2	231..254	CDD:290200
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		zf-H2C2_2	287..312	CDD:290200
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368
		zf-H2C2_2	344..366	CDD:290200
		C2H2 Zn finger	359..379	CDD:275368
		zf-H2C2_2	371..396	CDD:290200
		COG5048	383..823	CDD:227381	80/236 (34%)
		C2H2 Zn finger	387..407	CDD:275368
		zf-H2C2_2	399..423	CDD:290200
		C2H2 Zn finger	415..435	CDD:275368
		zf-H2C2_2	427..450	CDD:290200
		C2H2 Zn finger	443..463	CDD:275368
		zf-H2C2_2	455..478	CDD:290200
		C2H2 Zn finger	471..491	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		C2H2 Zn finger	527..547	CDD:275368
		zf-H2C2_2	539..562	CDD:290200
		C2H2 Zn finger	555..575	CDD:275368	1/2 (50%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		zf-H2C2_2	623..648	CDD:290200	12/24 (50%)
		C2H2 Zn finger	639..659	CDD:275368	9/19 (47%)
		zf-H2C2_2	651..676	CDD:290200	15/30 (50%)
		C2H2 Zn finger	667..687	CDD:275368	7/25 (28%)
		C2H2 Zn finger	695..715	CDD:275368	1/19 (5%)
		C2H2 Zn finger	723..743	CDD:275368	4/19 (21%)
		C2H2 Zn finger	751..771	CDD:275368	9/21 (43%)
		zf-H2C2_2	763..787	CDD:290200	9/23 (39%)
		C2H2 Zn finger	779..799	CDD:275368	5/19 (26%)
		zf-H2C2_2	791..816	CDD:290200	2/9 (22%)
		C2H2 Zn finger	807..827	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000