DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF549

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001186224.2	Gene:	ZNF549 / 256051	HGNCID:	26632	Length:	640	Species:	Homo sapiens

Alignment Length:	233	Identity:	72/233 - (30%)
Similarity:	113/233 - (48%)	Gaps:	40/233 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 KRHRTTGKDHTCDICDRRFSEAYNLRIHKMT--------HTDEKPHVCVECGKGFRQLNKLRIHA 146
            :|.....|.:.|:||.:.|       :||.|        ||.|:.:||:||||.......|..|.
Human   266 QRTHNAEKPYVCNICGKSF-------LHKQTLVGHQQRIHTRERSYVCIECGKSLSSKYSLVEHQ 323

  Fly   147 VTHTAERPHKCDICGKGFRYANYLTVH-RRLHTGEKPYPCLATDCHLSFHSIHARRIHTKLRHAA 210
            .||..|:|:.|::|||.||:......| :|:||||:||.|:  :|..||  ||:   :.::||
Human   324 RTHNGEKPYVCNVCGKSFRHKQTFVGHQQRIHTGERPYVCM--ECGKSF--IHS---YDRIRH-- 379

  Fly   211 QTDPDPEHPLAEQEQRDTSALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSA 275
                         ::..|...::.|..|.:....:..|..|.:.|..:|.:.|  .||||.|...
Human   380 -------------QRVHTGEGAYQCSECGKSFIYKQSLLDHHRIHTGERPYEC--KECGKAFIHK 429

  Fly   276 SELKHHQIAHTQQRPFACPLCPARFLRKSNHKQHLKVH 313
            ..|..||..||.::|:.|.:|...|:|.|::.:|.::|
Human   430 KRLLEHQRIHTGEKPYVCIICGKSFIRSSDYMRHQRIH 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	7/27 (26%)
		zf-H2C2_2	113..138	CDD:290200	12/32 (38%)
		C2H2 Zn finger	129..149	CDD:275368	7/19 (37%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	31/113 (27%)
		C2H2 Zn finger	157..177	CDD:275368	8/20 (40%)
		C2H2 Zn finger	185..206	CDD:275368	6/20 (30%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
ZNF549	NP_001186224.2	KRAB	27..67	CDD:307490
		COG5048	223..603	CDD:227381	72/233 (31%)
		C2H2 Zn finger	224..241	CDD:275368
		C2H2 Zn finger	249..269	CDD:275368	1/2 (50%)
		C2H2 Zn finger	277..298	CDD:275368	7/27 (26%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..355	CDD:275368	8/20 (40%)
		C2H2 Zn finger	363..383	CDD:275368	8/41 (20%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		C2H2 Zn finger	419..439	CDD:275368	9/21 (43%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		zf-H2C2_2	600..624	CDD:316026
		C2H2 Zn finger	615..635	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910