DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and Zfp27

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001032796.1	Gene:	Zfp27 / 22689	MGIID:	99174	Length:	819	Species:	Mus musculus

Alignment Length:	342	Identity:	101/342 - (29%)
Similarity:	151/342 - (44%)	Gaps:	67/342 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDL-------SGERLPMEME---LLNPGSEYDLLELVNGALQQRNTTEHKPTDM 80
            |.|..::|.|...|       :||:|.:.:|   ..:..||:        ...|:..|..||...
Mouse   179 CAEFGKIFTQKSQLRVHVTSPTGEKLYVCVECGKACSQTSEF--------LTHQKTHTREKPYKC 235

  Fly    81 --CKPK--RTPTTKRHR---TTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQ 138
              |...  :..:..|||   |..|.:.|..|.:.||...:||||:..||.||.|.||:|||.|.|
Mouse   236 GDCGKSFFQVSSLFRHRRIHTGEKLYDCSHCGKGFSYNSDLRIHQKIHTGEKRHGCVDCGKAFTQ 300

  Fly   139 LNKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFHS-----IH 198
            .:.||:|...||.||.:.|..||:.|....:|..|||:|||||||.|  ..|..:|.|     :|
Mouse   301 KSTLRMHQKIHTGERAYVCIECGQAFIQKTHLVAHRRIHTGEKPYAC--DGCGKAFLSKSQLLVH 363

  Fly   199 ARRIHTKLRHAAQTDPDPEH-------PLAEQEQRDTSAL------SFT---------------- 234
             :|||:::|.....|.....       |..:.:.|:.|::      :||
Mouse   364 -QRIHSRVRPCVSLDRAKPFSSAPNLLPRKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEK 427

  Fly   235 ---CPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLC 296
               |..|.:..|.:..|::|.:.|..::.:.|  .:||..|...:.|..||:.||.::|:.|..|
Mouse   428 PYQCGDCGKAFTQKSALTVHRRIHTGEKSYVC--VKCGLAFVQRAHLDAHQVIHTGEKPYQCGHC 490

  Fly   297 PARFLRKSNHKQHLKVH 313
            ...|..||....|.::|
Mouse   491 GKFFTSKSQLHVHKRIH 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	8/19 (42%)
		zf-H2C2_2	113..138	CDD:290200	15/24 (63%)
		C2H2 Zn finger	129..149	CDD:275368	10/19 (53%)
		zf-H2C2_2	142..166	CDD:290200	11/23 (48%)
		COG5048	151..>264	CDD:227381	38/149 (26%)
		C2H2 Zn finger	157..177	CDD:275368	8/19 (42%)
		C2H2 Zn finger	185..206	CDD:275368	8/25 (32%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	7/21 (33%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
Zfp27	NP_001032796.1	KRAB	2..37	CDD:366587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123
		C2H2 Zn finger	152..171	CDD:275370
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	207..227	CDD:275368	4/27 (15%)
		COG5048	<212..372	CDD:227381	62/170 (36%)
		C2H2 Zn finger	235..255	CDD:275368	4/19 (21%)
		C2H2 Zn finger	263..283	CDD:275368	8/19 (42%)
		C2H2 Zn finger	291..311	CDD:275368	10/19 (53%)
		COG5048	317..746	CDD:227381	53/196 (27%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		C2H2 Zn finger	347..367	CDD:275368	6/22 (27%)
		C2H2 Zn finger	403..423	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..451	CDD:275368	5/19 (26%)
		C2H2 Zn finger	459..479	CDD:275368	7/21 (33%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		C2H2 Zn finger	515..535	CDD:275368
		C2H2 Zn finger	543..563	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		C2H2 Zn finger	599..619	CDD:275368
		C2H2 Zn finger	627..647	CDD:275368
		C2H2 Zn finger	655..675	CDD:275368
		C2H2 Zn finger	683..703	CDD:275368
		C2H2 Zn finger	711..731	CDD:275368
		C2H2 Zn finger	739..759	CDD:275368
		zf-H2C2_2	752..775	CDD:372612
		C2H2 Zn finger	767..787	CDD:275368
		zf-H2C2_2	779..804	CDD:372612
		C2H2 Zn finger	795..815	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000