DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF585A

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001275729.1	Gene:	ZNF585A / 199704	HGNCID:	26305	Length:	769	Species:	Homo sapiens

Alignment Length:	345	Identity:	107/345 - (31%)
Similarity:	148/345 - (42%)	Gaps:	71/345 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VCLEDLQLFAQLEDL-------SGERLPMEMELLNPGSEYDLLELVNGALQ--QRNTTEHKP--- 77
            :|:|..|.|.|...|       :||: |.|..  |.|..:    :....||  ||..|..||
Human   271 ICIECGQAFIQKTHLIAHRRIHTGEK-PYECS--NCGKSF----ISKSQLQVHQRVHTRVKPYIC 328

  Fly    78 TDMCK----PKRTPTTKRHRTTGKDHTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQ 138
            |:..|    .....|.|:.::..|...|..|.:.|:....|.||:..||.|||:.|.:|||.|.|
Human   329 TEYGKVFSNNSNLVTHKKVQSREKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSDCGKAFTQ 393

  Fly   139 LNKLRI----------------------------HAVTHTAERPHKCDICGKGFRYANYLTVHRR 175
            .:.|.:                            |.:.||.|:||||..|||.|...:.|.||:|
Human   394 KSALTVHQRIHTGEKSYICMKCGLAFIQKAHLIAHQIIHTGEKPHKCGHCGKLFTSKSQLHVHKR 458

  Fly   176 LHTGEKPYPCLATDCHLSF----HSIHARRIHT--------KLRHAAQTDPDPEHPLAEQEQRDT 228
            :|||||||.|  ..|..:|    :.|..::.||        |...|.....|    |...::..|
Human   459 IHTGEKPYMC--NKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSD----LITHQRIHT 517

  Fly   229 SALSFTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFAC 293
            ....:.|..|.:..|.:.:|:||.|.|..:|.:.|  .||||.|...|.|..||..||.::|:.|
Human   518 GEKPYECNTCGKAFTQKSHLNIHQKIHTGERQYEC--HECGKAFNQKSILIVHQKIHTGEKPYVC 580

  Fly   294 PLCPARFLRKSNHKQHLKVH 313
            ..|...|:||||...|.::|
Human   581 TECGRAFIRKSNFITHQRIH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	13/24 (54%)
		C2H2 Zn finger	129..149	CDD:275368	8/47 (17%)
		zf-H2C2_2	142..166	CDD:290200	13/51 (25%)
		COG5048	151..>264	CDD:227381	40/124 (32%)
		C2H2 Zn finger	157..177	CDD:275368	9/19 (47%)
		C2H2 Zn finger	185..206	CDD:275368	6/32 (19%)
		C2H2 Zn finger	235..255	CDD:275368	7/19 (37%)
		C2H2 Zn finger	263..285	CDD:275368	10/21 (48%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
ZNF585A	NP_001275729.1	C2H2 Zn finger	748..768	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		COG5048	184..529	CDD:227381	78/270 (29%)
		C2H2 Zn finger	188..208	CDD:275368
		zf-H2C2_2	200..225	CDD:290200
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		zf-H2C2_2	284..309	CDD:290200	7/31 (23%)
		C2H2 Zn finger	300..320	CDD:275368	6/25 (24%)
		C2H2 Zn finger	328..347	CDD:275370	4/18 (22%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..393	CDD:290200	13/24 (54%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		C2H2 Zn finger	412..432	CDD:275368	1/19 (5%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		zf-H2C2_2	455..477	CDD:290200	13/23 (57%)
		C2H2 Zn finger	468..488	CDD:275368	4/21 (19%)
		COG5048	476..768	CDD:227381	39/131 (30%)
		C2H2 Zn finger	496..516	CDD:275368	4/23 (17%)
		zf-H2C2_2	508..533	CDD:290200	5/28 (18%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	12/26 (46%)
		C2H2 Zn finger	552..572	CDD:275368	10/21 (48%)
		C2H2 Zn finger	580..600	CDD:275368	8/19 (42%)
		zf-H2C2_2	592..617	CDD:290200	3/9 (33%)
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	636..656	CDD:275368
		zf-H2C2_2	648..673	CDD:290200
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_2	676..700	CDD:290200
		C2H2 Zn finger	692..712	CDD:275368
		zf-H2C2_2	705..728	CDD:290200
		C2H2 Zn finger	720..740	CDD:275368
		zf-H2C2_2	732..757	CDD:290200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000