DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2120 and ZNF780B

DIOPT Version :9

Sequence 1:	NP_572446.2	Gene:	CG2120 / 31737	FlyBaseID:	FBgn0030005	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	XP_005258647.1	Gene:	ZNF780B / 163131	HGNCID:	33109	Length:	834	Species:	Homo sapiens

Alignment Length:	341	Identity:	102/341 - (29%)
Similarity:	141/341 - (41%)	Gaps:	65/341 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLEDLQLFAQLEDL-------SGERLPMEMELLNPGSEYDLLELVNGALQQRNT-TEHKPTDMCK 82
            |.|..:.|..|..|       .||: |.|..  ..|..:.||..:|   :.:|. |..||.: ||
Human   336 CKECRKAFTLLTKLVRHQKIHMGEK-PFECR--ECGKAFSLLNQLN---RHKNIHTGEKPFE-CK 393

  Fly    83 P-----KRTPTTKRHRTTGKD---HTCDICDRRFSEAYNLRIHKMTHTDEKPHVCVECGKGFRQL 139
            .     .|:....:|::...|   :.|..|.:.|:...||..|:..|::|||.||.||...||..
Human   394 ECGKSFNRSSNLIQHQSIHADVKPYECKECGKGFNRGANLIQHQKIHSNEKPFVCRECEMAFRYH 458

  Fly   140 NKLRIHAVTHTAERPHKCDICGKGFRYANYLTVHRRLHTGEKPYPCLATDCHLSFH--------- 195
            .:|..|...||..:|.:|..|||.|.....|..|:.:||||||:.|  .||..:|:
Human   459 YQLIQHCQIHTGGKPFECKECGKAFSLLTQLARHKNIHTGEKPFEC--KDCGKAFNRGSNLVQHQ 521

  Fly   196 SIH-------------ARRIHTKLRHAAQTDPDPEHP---------------LAEQEQRDTSALS 232
            |||             |.|:|.:|....:|... |.|               |.:.....|....
Human   522 SIHTGEKPYECKECGKAFRLHLQLSQHEKTHTG-EKPFECKECGKFFRRGSNLNQHRSIHTGKKP 585

  Fly   233 FTCPVCSRVLTDQCYLSIHLKRHYNQRDFPCPQPECGKRFFSASELKHHQIAHTQQRPFACPLCP 297
            |.|..|.:......:|..|.|.|..::.|.|  .||||.|...::|.||:..||.::||.|..|.
Human   586 FECKECGKAFRLHMHLIRHQKFHTGEKPFEC--KECGKAFSLHTQLNHHKNIHTGEKPFKCKECG 648

  Fly   298 ARFLRKSNHKQHLKVH 313
            ..|.|.||..||..:|
Human   649 KSFNRVSNLVQHQSIH 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2120	NP_572446.2	C2H2 Zn finger	101..121	CDD:275368	6/19 (32%)
		zf-H2C2_2	113..138	CDD:290200	12/24 (50%)
		C2H2 Zn finger	129..149	CDD:275368	7/19 (37%)
		zf-H2C2_2	142..166	CDD:290200	10/23 (43%)
		COG5048	151..>264	CDD:227381	38/149 (26%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..206	CDD:275368	10/42 (24%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..285	CDD:275368	9/21 (43%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
ZNF780B	XP_005258647.1	KRAB	6..67	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	168..188	CDD:275368
		zf-H2C2_2	180..203	CDD:290200
		COG5048	192..633	CDD:227381	88/308 (29%)
		C2H2 Zn finger	196..216	CDD:275368
		zf-H2C2_2	209..232	CDD:290200
		C2H2 Zn finger	224..244	CDD:275368
		C2H2 Zn finger	252..272	CDD:275368
		C2H2 Zn finger	280..300	CDD:275368
		C2H2 Zn finger	308..328	CDD:275368
		zf-H2C2_2	321..344	CDD:290200	2/7 (29%)
		C2H2 Zn finger	336..356	CDD:275368	5/19 (26%)
		zf-H2C2_2	349..372	CDD:290200	6/25 (24%)
		C2H2 Zn finger	364..384	CDD:275368	5/24 (21%)
		zf-H2C2_2	377..401	CDD:290200	7/27 (26%)
		C2H2 Zn finger	392..412	CDD:275368	4/19 (21%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	489..513	CDD:290200	12/25 (48%)
		C2H2 Zn finger	504..524	CDD:275368	5/21 (24%)
		zf-H2C2_2	516..539	CDD:290200	3/22 (14%)
		C2H2 Zn finger	532..552	CDD:275368	4/19 (21%)
		zf-H2C2_2	545..569	CDD:290200	4/24 (17%)
		C2H2 Zn finger	560..580	CDD:275368	1/19 (5%)
		zf-H2C2_2	572..595	CDD:290200	5/22 (23%)
		C2H2 Zn finger	588..608	CDD:275368	5/19 (26%)
		zf-H2C2_2	600..624	CDD:290200	10/25 (40%)
		C2H2 Zn finger	616..636	CDD:275368	9/21 (43%)
		COG5048	624..>700	CDD:227381	16/41 (39%)
		zf-H2C2_2	629..653	CDD:290200	10/23 (43%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	672..692	CDD:275368
		C2H2 Zn finger	700..720	CDD:275368
		zf-H2C2_2	713..735	CDD:290200
		C2H2 Zn finger	728..748	CDD:275368
		zf-H2C2_2	741..765	CDD:290200
		C2H2 Zn finger	756..776	CDD:275368
		C2H2 Zn finger	784..803	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000